The Tn antigen is structurally simple and biologically complex, as R. D. Cummings et al. explain in this week’s Review. Which new diagnostics and therapeutics could result from chemical and biological studies? In an Essay, G. Ercolani and L. Schiaffino discuss allosteric, chelate, and interannular cooperativity. The Highlights deal with polycyclic aromatic hydrocarbons with a singlet open-shell ground state (C. Lambert) and merging metal and NHC catalysis (N. T. Patil).
In the Communications section, J. M. Gordon et al. describe new nanostructures of MoS2 having an octahedral nanoscaled core with a smooth transition to quasi-spherical outer shells (see picture). C. J. Douglas et al. demonstrate how alkenes can be inserted into the carbonyl bond of esters. G. M. Whitesides et al. succeeded in the production of a “soft robot” based on pneumatic networks.