Two Platinums Fight Cancer Better than One

  • ChemPubSoc Europe Logo
  • Author: ChemViews
  • Published Date: 20 April 2011
  • Source / Publisher: ChemMedChem/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Two Platinums Fight Cancer Better than One

Related Societies

cis-Diamminedichloridoplatinum(II) (cisplatin) is one of the most commonly used anticancer drugs. Although platinum-based chemotherapy can cause serious side effects, its efficacy has prompted the design and synthesis of next-generation anticancer platinum(II) drugs which are effective against cancers that are typically resistant to chemotherapy, such as lung cancer and pancreatic cancer.


Masahiko Chikuma and co-workers, Osaka University of Pharmaceutical Sciences, Japan, have made a Pt(II) complex with remarkably high activity against pancreatic cancer. The complex is dinuclear, with a tetrazolate moiety bridging the two Pt centers. It was tested in vivo and was shown to inhibit tumor growth by 99 % relative to the untreated control.

Pancreatic cancer remains the fourth leading cause of cancer-related deaths in the United States.


Article Views: 2848

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


A product of ChemPubSoc Europe (16 European Chemical Societies)and Wiley-VCH