Two Platinums Fight Cancer Better than One

  • Author: ChemViews
  • Published Date: 20 April 2011
  • Source / Publisher: ChemMedChem/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
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cis-Diamminedichloridoplatinum(II) (cisplatin) is one of the most commonly used anticancer drugs. Although platinum-based chemotherapy can cause serious side effects, its efficacy has prompted the design and synthesis of next-generation anticancer platinum(II) drugs which are effective against cancers that are typically resistant to chemotherapy, such as lung cancer and pancreatic cancer.

Masahiko Chikuma and co-workers, Osaka University of Pharmaceutical Sciences, Japan, have made a Pt(II) complex with remarkably high activity against pancreatic cancer. The complex is dinuclear, with a tetrazolate moiety bridging the two Pt centers. It was tested in vivo and was shown to inhibit tumor growth by 99 % relative to the untreated control.

Pancreatic cancer remains the fourth leading cause of cancer-related deaths in the United States.

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Magazine of Chemistry Europe (16 European Chemical Societies)published by Wiley-VCH