D. A. Leigh et al. present strategies and tactics for the syntheses of rotaxanes, knots, catenanes, and higher-order links in a Review: Metal control gives access to a variety of product topologies such as trefoil knots, Solomon links, and Borromean rings. In a Minireview, N. Martín et al. discuss the role of macrocycles and cages as hosts for fullerenes. The Highlights deal with magnesium hydride clusters for hydrogen storage (E. Hevia and R. E. Mulvey) and the precision synthesis of biodegradable polymers (C. M. Thomas and J.-F. Lutz).
In the Communications section, H. B. Gray et al. report on nitrogen insertion into a corrole ring as a route to rare porphyrinoids. D. Belder et al. achieved optimization of reactions with minimal consumption of resources in a short period of time by integrating asymmetric organocatalysis and analysis on a chip (see picture). A dual-imaging probe with gold nanoparticles (AuNPs) for computed tomography and optical imaging exhibits was developed by K. Kim et al. by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes.