Sensitive and Selective Dopamine Sensor

Sensitive and Selective Dopamine Sensor

Author: ChemPlusChem

Graphene has become widely used in the field of analytical electrochemistry. This is because a graphene-modified interface can provide a large electrochemically active area and leads to high detection sensitivity.

As a result of a collaborative study between researchers at the Chinese Academy of Sciences and King Abdulaziz University, Jeddah, Saudi Arabia, Xuping Sun and his team have fabricated a graphene-on-gold electrode that can be used for detecting dopamine (DA). The approach exploits interactions between graphene and DNA bases using thiolated single-stranded DNA as a linker and π-π stacking interactions (see figure). Because graphene can absorb the carbon-based rings of DA in a stable manner and retain the excellent conductivity of the gold electrode, the sensor exhibits high sensitivity and selectivity in the presence of ascorbic acid and has a detection limit for DA of 0.8 nm.

This is a new approach for using graphene-on-gold substrates as sensors where the electrode fabrication process is complete within 30 minutes.

Image: © Wiley-VCH

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