2011 Trends in Biochemistry

2011 Trends in Biochemistry

Author: ChemViews/GDCh

Nachrichten aus der Chemie (the membership magazine of the GDCh) annually publishes trend reports in which authors spot and compile an overview of inspiring work and recent trends in the most important chemical disciplines.

ChemViews gives you an overview of the latest trend report, its authors and the literature collected.

Trends in Biochemistry 2011

M. Helm, M. Mörl, P. F. Stadler, S. Hoffmann, C. Höbartner

  • RNA: Deep sequencing is the next step in the RNA revolution.
  • Epigenetics: 5-Hydroxymethylcytosine, the sixth base in the genome, is discussed as a novel epigenetic modification.

► Full article (in German):

Trendbericht Biochemie 2011,

All 2011 trend reports on ChemViews


Mark HelmMark Helm, born 1969, has been a Professor of Pharmaceutical/Medicinal Chemistry at the University of Mainz, Germany, since 2009. He received his Ph.D. in 1999 in molecular biology at the University of Strasbourg, France, after which he undertook postdoctoral research at the California Institute of Technology, USA, and at the Freie Universität Berlin, Germany. After that, he became a Senior Research Scientist in the Department of Chemistry at the Institute of Pharmacy and Molecular Biotechnology of the University of Heidelberg, Germany, where he obtained his Habilitatation in 2008 in the fields of pharmaceutical chemistry and biochemistry.

His research interests include ribonucleotide modification, the structural dynamics of RNA molecules, the uptake and intracellular distribution of siRNA, and RNA bioconjugates.

Mario MörlMario Mörl, born 1960, studied biology at the Ludwig Maximilian University of Munich, Germany. There, he completed his Ph.D. on ribozymes before becoming a Postdoctoral Fellow and Research Assistant to S. Pääbo. In 1999, he became Group Leader at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany. He completed his Habilitation in 2002 in genetics and he has been Professor of Biochemistry and Molecular Biology at the University of Leipzig since 2004.

His research interests include the evolution of RNA-specific nucleotidyltransferases, tRNA editing events, as well as the in vitro evolution of RNA aptamers.

Peter StadlerPeter F. Stadler, born 1965, has been a Professor of Bioinformatics at the University of Leipzig, Germany, since 2002. He received his Ph.D. in chemistry from the University of Vienna, Austria, in 1990. After a postdoctoral fellowship at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany, he returned to Vienna in 1991 and received his Habilitation in theoretical chemistry in 1994. Since 1994, he has also been an External Professor at the Santa Fe Institute in New Mexico, USA, and, since 2009, he has acted as an External Scientific Member at the Max Planck Institute for Mathematics in the Sciences in Leipzig.

His research interests include bioinformatics with an emphasis on structural biology and comparative genomics, non-coding RNAs, the mathematical foundations of evolutionary biology, and discrete mathematics.

Steve HoffmannSteve Hoffmann, born 1978, is the Director of the Research Group for Transcriptome Bioinformatics in the LIFE Center for Lifestyle Diseases at the University of Leipzig, Germany. He has a doctorate in medicine and bioinformatics.

He is interested in the design of algorithms and methods for the evaluation of high-throughput data-sequencing.

Claudia HöbartnerSince 2008, Claudia Höbartner, born 1977, has led the Max-Planck Research Group for Nucleic Acid Chemistry at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany. She studied chemistry at the Technical University of Vienna, Austria, and at the ETH Zurich, Switzerland, and received her Ph.D. at the University of Innsbruck, Austria, in 2004. She took up a position as a Postdoctoral Fellow at the University of Illinois, Urbana-Champaign, USA.

Her research interests focus on chemically modified nucleic acids and catalytically active DNA.


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5-Hydroxymethylcytosine in the Genome

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Image: © Wiley-VCH, from ChemBioChem 13/2011 cover

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