New Route to Aminohydantoins

  • Author: European Journal of Organic Chemistry
  • Published Date: 17 May 2012
  • Source / Publisher: European Journal of Organic Chemistry/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: New Route to Aminohydantoins

Related Societies

Hydantoins are an important class of compounds, as they can be used as building blocks for the synthesis of therapeutic drugs. The hydantoin core structure can be found in drugs associated with the treatment of epileptic seizures, metastatic prostate cancer, and cardiac arrhythmias. Moreover, the hydantoin scaffold is a very attractive template for combinatorial synthesis due to its large number of possible substitution patterns and interesting combination of potential hydrogen-bond donors and acceptors on the small five-member ring system. Therefore, the efficient synthesis of a diverse library of hydantoins is attractive.

A Korean team headed by Ge Hyeong Lee, Korea Research Institute of Chemical Technology, Daejeon, has reported a new protocol for the synthesis of a diverse aminohydantoin library starting from a variety of amino amides and isocyanates or isothiocyanates. Intramolecular cyclization of thioureas or ureas tethered to amides afforded the aminohydantoins in very high yields regardless of the substituent (alkyl or aryl).

This method is attractive because the starting materials are readily available and the reaction can be performed under mild conditions. Importantly, the chiral centers remain intact under the reaction conditions, which makes this method even more valuable.

Article Views: 3680

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from, please contact us first for permission and consult our permission guidance prior to making your request

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH