Nanoparticles with a Double Nature

  • Author: Melania Tesio
  • Published Date: 30 November 2012
  • Source / Publisher: Angewandte Chemie International Edition/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
thumbnail image: Nanoparticles with a Double Nature

Magnetic nanoparticles generate heat following exposure to a magnetic field. This property has been exploited to kill cancer cells as heat provokes apoptosis, a programmed cell death. In order to achieve a therapeutic effect, however, it is necessary to expose tumors to high temperatures which can be detrimental also for normal tissues.

Dongwon Yoo, Yonsei University, Korea, and colleagues report a way around this problem. The researchers conjugated Zn0.4Fe2.6O4 magnetic nanoparticles to gadolinium(III) texaphyrin, a porphyrin which induces reactive oxygen species (ROS) in cancer cells. The generation of this oxidative stress rendered tumor cells more susceptible to apoptosis when using magnetic heat treatments at 43 °C, a temperature that does not affect healthy cells. When delivered to cancer-bearing mice, these nanoparticles effectively reduced the tumor growth.

Thanks to this strategy, it is possible to achieve an efficient heat-induced apoptosis of tumor cells even at mild temperatures.

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