Bispirooxindole Derivatives

Bispirooxindole Derivatives

Author: Saskia Neubacher

An efficient synthesis of spirooxindole derivatives is highly valued due to the pronounced biological activities of this class of compounds.

Min Shi and colleagues, East China University of Science and Technology / Chinese Academy of Science, Shanghai, have developed a highly regio- and stereoselective synthesis of bispirooxindoles. In the three-component reaction, azomethine ylides are generated in situ from isatin derivatives and proline, which can then react with different electron-deficient alkenes in a 1,3-dipolar cycloaddition, finally affording bispiro scaffold compounds in excellent yields. 
The stereochemistry was determined by single-crystal X-ray analysis.


 

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