In-line Improvement

In-line Improvement

Author: Rosalyne Cowie

The power of using flow chemistry for multistep, multicomponent coupling processes to develop functional molecules with commercial applications and potential healthcare benefits is rapidly increasing.

Steven Ley and co-workers, Cambridge, United Kingdom, have developed a continuous flow synthesis of N,N-diethyl-4-(3-fluorophenylpiperidin-4-ylidenemethyl)benzamide, which is a potent δ-opioid receptor agonist developed by AstraZeneca.

The four-step process employs a sequence of flow-based microreactors, with integrated purification employing solid-supported reagents and in-line IR analytical protocols using a newly developed ReactIR flow cell.

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