Design of Polymeric Porous Adsorbent Media

Design of Polymeric Porous Adsorbent Media

Author: Elmar Zimmermann

For practical design and operation of the ion exchange chromatography (IEC) bioseparation systems employed in industry, macroscopic continuum modeling of system-wide dynamics is needed. This requires a qualitative and quantitative knowledge of the characteristics of porous polymeric IEC adsorbent media, including mass transfer and adsorption mechanisms, and rates of the adsorbate biomolecule in the porous media.

Jee-Ching Wang and Athanasios I. Liapis, Missouri University of Science and Technology, USA, developed and employed a systematic methodology and a complete machinery for the construction, study, and design of porous polymeric adsorbent media for bioseparations. They use a combination of molecular dynamics modeling and simulations and macroscopic continuum modeling. The methodology can also be extended to studies of other systems employing porous media including systems involving monoliths, metal-organic-frameworks (MOFs), membranes, and biocatalysts.


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