Hydrogels - Enhanced Swelling Ratios

  • Author: ChemViews
  • Published Date: 01 January 2011
  • Source / Publisher: Chemistry - An Asian Journal/Wiley-VCH
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
thumbnail image: Hydrogels - Enhanced Swelling Ratios

Thermoresponsive hydrogels, which undergo a specific volume change upon crossing the lower critical solution temperature (LCST), have received a great deal of attention owing to their potential utility in various applications including drug delivery, regenerative medicine, responsive membranes, molecular machines, nanotemplates, biosensors, catalysis, and photonic crystals.

Scientists around T. Kowalewski and K. Matyjaszewski, Carnegie Mellon University, Pittsburgh, PA, USA, have describe a novel approach to prepare rapid-response thermoresponsive hydrogels with enhanced swelling ratios.
They stabilized thermoresponsive hydrogels based on poly(2-(2-methoxyethoxy)ethyl methacrylate) by atom transfer radical polymerization (ATRP), using core-degradable, hydrophilic-arm-containing star macroinitiators. The subsequent degradation of disulfide crosslinks generated hydrogels with hydrophilic porous domains. This unique strategy enabled the preparation of highly swelling and rapidly deswelling hydrogels.

The hydrogels with this unique porous structure were shown to be capable of quickly releasing amphiphilic drug model molecules upon increasing the temperature above LCST, and were non-cytotoxic, which points to their potential applicability as biomaterials.


Article Views: 3463

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

Bookmark and Share

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more


CONNECT:

ChemistryViews.org on Facebook

ChemistryViews.org on Twitter ChemistryViews.org on YouTube ChemistryViews.org on LinkedIn Sign up for our free newsletter


Magazine of Chemistry Europe (16 European Chemical Societies)published by Wiley-VCH