Next Generation of Dendritic Nanocarriers

Next Generation of Dendritic Nanocarriers

Author: ChemViews

A team of scientist around Holger Stephan, Forschungszentrum Dresden-Rossendorf, Institute of Radiopharmacy, Dresden, Germany, has studied the encapsulation and release of nanometer-sized anionic rhenium cluster complexes in biocompatible maltose-decorated dendrimers. They have shown that sugar-capped POPAM dendrimers are well suited to encapsulate and slowly release nanosized guest molecules, such as the anionic hexanuclear rhenium cluster complexes.
Results obtained from time-resolved laser fluorescence spectroscopy indicate that guest molecules are partially de-solvated during the process of inclusion.

These and other features described by the authors may be utilized for the development of novel drug-delivery
systems. The synthetic pathway conveniently allows the modification of dendrimer surfaces with additional biologically
active molecules, hence offering great potential for using such dendritic nanocontainers for targeting in vivo.


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