Carbon Monoxide Powder

  • Author: ChemistryViews
  • Published: 09 April 2011
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Journal of the American Chemical Society/ACS Publications

Carbon monoxide is used in many chemical syntheses. It is a colorless, odorless gas that is highly toxic. Exposure to CO is hard to detect until the late stages so it must be handled with extreme caution. Troels Skrydstrup and co-workers, Aarhus University, Denmark, have developed a harmless powder, which when treated with a catalyst can release CO for use in organic reactions.


The team used a sealed two-chamber system with a CO-producing chamber and a CO-consuming chamber. A stable and solid acid chloride derivative was decarbonylated by a palladium catalyst. The resultant CO then diffused into the CO-consuming chamber where a range of carbonylation reactions were performed leading to several pharmaceutically relevant compounds.


This technique will be of high value for synthetic chemists, not only as a new source of a safe and storable CO gas, but also because of its ease in handling and straightforward use in CO related chemistry, including isotope labeling studies.


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