New Dual Catalyst Approach

New Dual Catalyst Approach

Author: David Bradley

US researchers have used a dual catalyst consisting of a chiral primary aminothiourea and a second achiral thiourea to effect enantioselective intramolecular [5 + 2] cycloadditions based on oxidopyrylium intermediates. Their analysis of the reactions suggests that a new type of cooperative catalysis takes place in which each component is essential for generating a reactive pyrylium ion pair (pictured) which allows the subsequent cycloaddition to occur with high enantioselectivity.

[5 + 2] cycloadditions are widely used in organic synthesis so this approach offers a new approach to valuable tricyclic structures.

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