Uniquely Fluorescent

  • Author: David Bradley
  • Published: 14 January 2012
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Journal of the American Chemical Society/ACS Publications
thumbnail image: Uniquely Fluorescent

A team at Hunan University, Changsha, China, has developed a new class of switchable fluorescent dyes that reduce the amount of photodamage, but do not compromise deep tissue penetration, in the fluorescence imaging of living animals. Additionally, there is minimum background autofluorescence interference with the new near-IR fluorophores named CS, for Changsa.

The six new dyes CS1-6 are based on the traditional rhodamine dyes (blue), but are superior to rhodamine dyes as they have both absorption and emission in the near-IR region while retaining the rhodamine-like fluorescence ON-OFF switching mechanism, the team says.

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