Deracemize to Reracemize

Deracemize to Reracemize

Author: ChemViews

Wolfgang Kroutil and co-workers from the University of Graz, Austria, highlight the deracemization of mandelic acid to optically pure L-phenylglycine via a redox-neutral biocatalytic cascade, in their recent communication.

The procedure consisted of three steps:

  1. a racemization,
  2. an enantioselective oxidation, and
  3. a stereoselective reductive amination.

Racemic mandelic acid was transformed to optically pure L-phenylglycine (ee >97 %) at 94 % conversion without the requirement of any additional redox reagents in stoichiometric amounts.

(C) Wiley-VCH

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