Mesoporous silica nanoparticles (MSNs), feature well-defined nano-sized pores, and have therefore been actively studied as drug delivery vehicles. However, their performance is greatly challenged by cargo leakage and premature release.
Ying-Wei Yang at Jilin University, Changchun, China, Hui Gao at Tianjin University of Technology, Tianjin, China, and colleagues have developed a layer-by-layer coating strategy based on non-covalent interactions for building pH-responsive MSN drug carriers. Loaded with anticancer drugs, the MSNs are coated with cucurbituril-bridged polymer layers, where the amine terminals of the polymer are encapsulated in cucurbituril. In low pH environments, such as cancer cells, the coating dissembles and triggers the release of drugs.
The researchers have demonstrated both in vitro and in vivo cancer cell-targeting drug delivery with high efficiency using this system. As an inherently flexible functionalization method for MSNs, its selective response can be easily tuned by changing coating units.
- Mesoporous Silica Nanoparticles Coated by Layer-by-Layer Self-assembly Using Cucurbituril for in Vitro and in Vivo Anticancer Drug Release
Qing-Lan Li, Yanfang Sun, Yu-Long Sun, Jijie Wen, Yue Zhou, Qi-Ming Bing, Lyle D. Isaacs, Yinghua Jin, Hui Gao, Ying-Wei Yang
Chem. Mater. 2014.