Gel Patches with Antibacterial Properties

  • Author: Lisa-Marie Rauschendorfer
  • Published: 09 April 2015
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
  • Source / Publisher: Engineering in Life Sciences/Wiley-VCH
thumbnail image: Gel Patches with Antibacterial Properties

Hydrogels from natural polymers could be very useful for the production of patches, as their physical and chemical properties can be easily tuned by the extent of cross-linking. They also provide a moist environment beneficial for healing. However, until now cross-linking up is associated with the use of toxic chemical linkers, making hydrogels unsuitable for medical applications.


Tzanko Tzanov and colleagues, University Politecnica de Terrassa, Barcelona, Spain, used the enzyme enzyme horseradish peroxidase (HRP) to catalyze the cross-linking of hydrogels from thiolated chitosan in order to avoid harsh chemical cross-linking materials. The team is able to incorporate polyphenolic nanospheres (NSs) from epigallocatechin gallate (EGCG) using this enzyme-mediated gelation. These spheres reinforce the hydrogel structure and are released intact in a sustained manner over 6 days from the hydrogel. EGCG-NSs even show better antibacterial properties than EGCG in solution, but no cytotoxic effect on human cells.


The good biocompatibility of the gel, together with the antibacterial effect of the EGCG-NSs, suggest a promising application in wound management.


 

Article Views: 3256

Sign in Area

Please sign in below

Additional Sign In options

Please note that to comment on an article you must be registered and logged in.
Registration is for free, you may already be registered to receive, e.g., the newsletter. When you register on this website, please ensure you view our terms and conditions. All comments are subject to moderation.

Article Comments - To add a comment please sign in

If you would like to reuse any content, in print or online, from ChemistryViews.org, please contact us first for permission. more

Follow on Facebook Follow on Twitter Follow on YouTube Follow on LinkedIn Follow on Instagram RSS Sign up for newsletters

Magazine of Chemistry Europe (16 European Chemical Societies) published by Wiley-VCH