Prevention Better Than Cure

Prevention Better Than Cure

Author: ChemistryViews

A tumor’s angiogenic switch is dependent on its ability to recruit a blood supply. Without a blood supply, a tumor is unable to grow. Due to the many driving factors behind angiogenesis, there are many targets for therapeutic intervention.

Ronit Satchi-Fainaro, Tel Aviv University, Israel, has reviewed multifunctional drug delivery strategies for a special issue of the Israel Journal of Chemistry on polymer therapeutics, of which she is also a guest editor. In the article she discusses the use of polymer-drug conjugates that target the tumor site. She notes that polymeric drug delivery systems are based on five common design themes:

  • The polymer-based backbone,
  • Drugs,
  • Spacers,
  • Targeting groups, and
  • Solubilizing agents.

Ronit Satchi-Fainaro discusses these in the context of different polymer backbones, with focus on HPMA copolymers, PEG, PGA and PG dendrimers and how these can be employed to deliver a tailored cocktail of drugs designed to prevent angiogenesis and thereby cancer growth.

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