Silvery Sheen for Fluorination

  • Author: David Bradley
  • Published: 27 August 2010
  • Copyright: Wiley-VCH Verlag GmbH & Co. KGaA
  • Source / Publisher: Journal of the American Chemical Society/ACS Publications
thumbnail image: Silvery Sheen for Fluorination

Fluorinated aromatics are used in drugs, agrochemicals, and in positron emission tomography tracers. Unfortunately, making carbon-fluorine bonds is hard and uses expensive palladium catalysts; for complex molecules it is harder still.


Now, Tobias Ritter and co-workers, Harvard University, USA, have remedied this situation and made it possible to fluorinate aryl groups, even in crowded molecules, using less-expensive silver to catalyze a cross-coupling reaction. Specifically, the team has proved the viability of the approach using silver oxide to catalyze the fluorination of aryl tin compounds with an electrophilic fluorine compound.


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