A concise synthesis of steviamine and three of its analogues is reported before testing for glycosidase inhibition
Sweet Route to Steviamine
Keeping Track of Internalization
A DNA-based sensor signals the internalization of proteins and nanoparticles into live cells
2013 Wolf Prize in Chemistry
The 2013 Wolf Prize is awarded to Robert Langer, USA, for his work on controlled-release drug delivery systems
Anti-adhesive β-Cyclodextrin Complexes Reduce E. coli Infection
Heptavalent n-heptyl α-D-mannosides on β-cyclodextrin cores are shown to inhibit bacterial adhesion in vivo
Photochemical Control of Pain
US researchers discovered a small molecule which renders pain transmitting neurons sensitive to light
Picture Competition – A Year in the Lab: The Chemist’s View
Submit your outstanding photo and have the chance to be selected for a calendar and win one of 12 exciting prizes
A Safe and Good Night’s Sleep
DORA-22, an orexin receptor antagonist, effectively treats insomnia without impairing memory and attention
Acetyl or Myristoyl: That is the Question
US scientists revealed that the sirtuin SIRT6 is not a deacetylase but a long-chain fatty-acyl hydrolase
DNA Logic Gates for Metal-ion Sensing
Electronic logic gates made from DNA in conjunction with metal-ion sensing could be used for point-of-care sensing devices
Preventing Geldanamycin’s Toxicity
Novel 19-substituted benzoquinone ansamycins inhibit heat shock protein 90 without causing toxic effects in vitro