Discovery of selectively adding a fluorine or trifluoromethyl group to biologically active compounds dramatically improve their properties

Catalytic Fluorination – Major Challenge

Method to Prepare tRNA Nucleosides
Turbo-Grignard reagent with specific point of attack allows synthesis of tRNA nucleosides in presence of reactive groups

Angewandte Chemie 46/2010: Food for Thought
An overview of the current issue of Angewandte Chemie International Edition

User Experience Research
Wiley are looking for organic chemists to participate in the usability testing of a new online chemistry content service Nov. 17/18

Mess-ter Comic – ROP is Easy!
A comic series by Sophie Lin: In part 3 she depicts how chemistry can sometimes surprise you

Make the Switch
Acid/base and anion exchange used to reversibly transition a urea-based [2]rotaxane between solution and gel states

Bismuth for Bone Cement
Water-soluble bismuth cluster is key to the formation of a hybrid material

Replacing a Ring with a Ball
Asborin, the carbaborane-containing analogue of aspirin, holds promise as lead structure for aldo/keto reductase (AKR) inhibition

Chirality by Stirring
Chirailty of supramolecular species determined by shear rate and drag forces from stirring flows

Easier Tubulysins: Delivered!
Delivery of tubulysin analogues using dendrimer conjugation technology promises efficacy without toxicity