A diverse library of compounds for pharmaceutical screening can be created starting with a single reactive natural product, according to US chemists

Molecular Remodeling

Switching On And Off the Chemical Light
Hindered photochromic benzo- and naphtho[1,3]oxazines can switch rapidly between colorless and colored forms under ultraviolet irradiation

Green and Efficient HMF Production
Production of 5-hydroxymethylfurfural (HMF) from fructose with a yield of up to 87 %

The B-Class Gets Some Class-A Help
Designing small-molecule ligands for class B GPCRs despite the lack of structural information for this receptor class

Recycling Catalysts by Precipitation
Simple way to recover and reuse chiral copper bis(oxazoline) complexes reported by French researchers

Synthesizing Rigid Bicycles
Polyprenylated polycyclic acylphloroglucines which have a range of activities can now be synthesized in just seven steps

New Guest-Accepting Organic Crystals
Organic alloys with guest-acceptor capabilities could allow crystal properties to be tuned by doping or mixing

A Better Target for B-Cell Lymphomas
Screening existing library of antagonists for binding affinity toward CD22 identifies new potential treatments for B-cell lymphomas

Side-effects Effectively Sidelined!
Canadian researchers have found a way to eliminate the liabilities of COX-2-specific inhibitors by introducing NO donor groups

Is Universal, Simple Melting Point Prediction Possible?
Prediction of the melting point of ionic liquids could allow structural refinement before the first synthesis