Use of visible or near-IR light to excite fluorophores attached to cobalamin complexes results in cleavage of the Co-C bond
Photoinduced Control of Bioactive Species
Total Chemical Synthesis of Erythropoietin
Total synthesis of homogeneous erythropoietin with consensus carbohydrate domains incorporated at all native glycosylation sites
Integrative Molecular Informatics for Drug Safety
Tools exploiting pharmacological similarity to highlight potential safety liabilities for molecules that may otherwise escape detection
Angewandte Chemie 52/2013: Fireworks
Overview of the latest issue of Angewandte Chemie
From Cholesterol to Breast Cancer
The conversion of cholesterol into 27-hydroxycholesterol promotes the growth of hormone-dependent breast cancer
Anchors for Biosensors
Graphene oxide, functionalized with carboxyl groups, have potential use in biosensors and drug delivery
A Drug Against Obesity?
Small synthetic molecule identified that ameliorates obesity-related disorders in animal models
Novartis Early Career Award in Organic Chemistry 2013
Nicolai Cramer, EPF Lausanne, Switzerland, and Daniel Rauh, Technische Universität, Dortmund, Germany, awarded
What Matters?
Alois Fürstner discusses how public perception of chemistry and lack of financial resources threaten basic research
Successful Teamwork
Unusual fungal metabolites with antitumor activity discovered by crowdsourcing