Synthesis and biological re-evaluation of the cytotoxic effects of Lactimidomycin and its progeny in cancer cells

Lactimidomycin – No Effect on Cell Motility but Still Cytotoxic

Machine-Assisted Flow Synthesis
Flow-based syntheses to accelerate multistep routes to highly complex, medically relevant compounds have been evaluated

Novel Therapeutic Target for Pancreatic Cancer
A non-canonical metabolism of the amino acid glutamine sustains pancreatic ductal adenocarcinoma’s growth

Most Accessed Articles: March 2013
The most-accessed chemistry articles from ChemPubSoc Europe and GDCh journals for March 2013

Novel Anti-influenza Drugs
Difluorosialic derivatives are a novel class of anti-influenza medicaments acting against drug-resistant viral strains

Werner Prize for C. Nevado and C. Mazet
Cristina Nevado, Zurich, and Clément Mazet, Genève, have been awarded the Werner Prize of the Swiss Chemical Society

Allergic to Animal Tests?
BASF and Promega develop an alternative method to identify allergenic substances

New Route to Antimalarial Artemisinin
A molybdenum-catalyzed synthesis of 1,2,4-trioxanes provides access to artemisinin and active analogues

Measuring Cell Cannibalism
New technique to quantify cell death by autophagy in vitro

Threading Drugs through DNA
DNA binding properties of binuclear ruthenium threading intercalators investigated with implications for design of new DNA binding drugs