In this issue’s Review, D. Neri et al. discuss the current state of small targeted cytotoxics. What are the promises from DNA-encoded chemical libraries? In a Minireview, N. Busschaert and P. A. Gale summarize research on anion transporters for biological applications. The Highlights deal with libraries of small molecules for phenotypic screening (M. Kaiser et al.) and rhodium iminocarbenes derived from N-sulfonyl triazoles (A. V. Gulevich and V. Gevorgyan).
In the Communications section, S. H. Friedmann et al. present a material that allows for insulin to be released in a controlled fashion by using light (see picture). F. Wudl et al. report on the hextuple Friedel–Crafts carbamylation in the synthesis of the electroactive decacyclene triimides, which are promising n-type materials for organic semiconducting devices. J. A. Ripmeester et al. succeeded in the preparation of cubic ice filled with hydrogen.