Sphingolipid analogs improve drug delivery across the blood-brain barrier by targeting the transporter P-glycoprotein

Improving Drug Delivery to the Brain

Glycosilated Dendrimers Protect the Gut
A glycosilated polypropyletherimine dendrimer defends gut wall’s integrity during infectious inflammatory diarrhea

Restrict DNA Freedom with PNA for White Light
Peptide nucleic acid (PNA) restricts the conformations of arranged chromophores on a DNA strand and improves its photophysical properties

ProcessNet 2012 Overview
Snapshots of the ProcessNet-Jahrestagung 2012 and the 30. DECHEMA-Jahrestagung der Biotechnologen in Karlsruhe, Germany

Rhenium-Centric Reverse Turn Mimics
Re complex provides access to reverse-turn mimics for diagnostic and therapeutic radiopharmaceuticals

Co-Immobilized Bi-Enzymatic Cascades
Cofactors are recycled in situ in bio-redox reactions over main and recycling dehydrogenases co-immobilized on porous supports

Peptidodendrimer Drug Delivery
Attachment of a membrane-interacting protein allows a dendrimer to enter cells, making it a potentially useful drug-delivery vehicle

Angewandte Chemie 38/2012: Only the Finest
Overview of the latest issue of Angewandte Chemie

Enzymes Dig Channels
Enzymatic etching used to build nano- and microscale surface topologies to allow easy and rapid detection of tumor cells in blood

Less Junk DNA Than Thought
The Encode Project, successor of the Human Genome Project, reveals biological functions of about 80 % of the DNA