HIV-1 integrase (IN) is an essential enzyme for HIV-1 replication: New routes to IN inhibition could overcome drug resistance

New Routes to IN Inhibition

Targeted Delivery with Self-Adjusting Magnet
Method to immobilize drug capsules without damaging surrounding tissue could lead to localized or increased drug absorption

3D Scaffold for Cell Cultures
Control over formation of cell adhesion sites and, consequently, cell shape in three dimensions can be achieved

Aerosol Transmission of Prions
Diseases caused by misfolded proteins such as mad cow disease could have an airborne route to infection

CO2 Transforms Pharmaceutical Crystal Forms
Carbon dioxide enables crystals to change shape into pharmaceutically interesting form under mild conditions

ChemistryViews Video Contest
Call for Submissions to the ChemistryViews Video Competition: 3 min video on Chemistry in Everyday Life

Finding Hidden Chirality
The importance of an often overlooked source of chirality, atropisomerism, depends upon the barriers to rotation

Improvement of COX-1 Inhibitors
Novel cyclooxygenase-1 inhibitors show promise as analgesics, with none of the previous side effects

Treating Resistant Infections with Silver
Silver N-heterocyclic carbenes are promising candidates for new topical antibacterial drugs due to high activity against resistant S. aureus

Angewandte Chemie 3/2011 – Natural Inspiration
Overview of the current issue of Angewandte Chemie International Edition