The Magazine of Chemistry Europe

Orexin receptor antagonist developed by Merck and currently in phase II trials promising for treating insomnia

Use of fluorophore increases the sensitivity and accuracy of the thrombin generation test for estimating blood's clotting ability

New CXCR4 antagonists found to be as potent as commercial drug in mobilizing stem cells

Synthesis of the best human acetylcholinesterase (AChE) inhibitors reported – important for treatment of Alzheimer's disease

Designing small-molecule ligands for class B GPCRs despite the lack of structural information for this receptor class

Canadian researchers have found a way to eliminate the liabilities of COX-2-specific inhibitors by introducing NO donor groups

Software screens virtual multi-component reaction products which can be rapidly synthesized and undergo a reality check by physical screening

Study of the structure–activity relationship of steroid sulfatase inhibitors explains why Irosustat is the best in its class

Screening technique using a nonlabeled reporter ligand for the human serotonin transporter could improve depression drugs

Modified, site- specific peptide triazole inhibitors target HIV-1 gp120 to physically disrupt virus particles in the absence of host cells