Author Archive for: Scott Williams (55)

A Drug Pipeline Going Dry

A Drug Pipeline Going Dry

The number of effective anti-tuberculosis (TB) drugs continues to dwindle; can we find new agents for treating drug-resistant TB?

New Routes to IN Inhibition

New Routes to IN Inhibition

HIV-1 integrase (IN) is an essential enzyme for HIV-1 replication: New routes to IN inhibition could overcome drug resistance

Finding Hidden Chirality

Finding Hidden Chirality

The importance of an often overlooked source of chirality, atropisomerism, depends upon the barriers to rotation

Two Birds, One Stone

Two Birds, One Stone

Single drug that blocks NO production by inhibiting two different enzyme targets could reduce tumor growth

Replacing a Ring with a Ball

Replacing a Ring with a Ball

Asborin, the carbaborane-containing analogue of aspirin, holds promise as lead structure for aldo/keto reductase (AKR) inhibition

Proteomic Approach

Proteomic Approach

A proteomics approach to protein binding provides a pull-down menu for medicinal chemists

Pièce de Résistance!

Pièce de Résistance!

Extremely potent compound against various multidrug-resistant HIV-1 variants developed