Synthesis and biological characterization of amidopropenyl hydroxamates as histone deacetylase inhibitors for cancer treatment

HDAC Inhibitors

Digging Deep
Journal of Physical Organic Chemistry presents a "Symposium in Print on Tunneling in Chemical and Biological Reactions"

Two at a Time
The ability of an electron to exist in two places at once has been controlled in the most common electronic material – silicon.

Asymmetric Antimalarial
An asymmetric total synthesis of the natural product erythro-8-O-4'-neolignan, machilin C, and its analog has been developed.

Water Off a Duck's Back
Switches between superhydrophobicity to superhydrophilic with pH could have important applications in medical applications.

Doubly Green Material
A porous solid that not only stores hydrogen gas but can soak up carbon dioxide; a potentially green material on two fronts.

Superoxide to the Rescue!
Reaction pathway between sodium atoms and oxygen molecules on solid surfaces probed by EPR spectroscopy.

Power Boost
Using carbon nanotubes as a battery’s electrode gives a tenfold increase in power by weight, compared to lithium-ion batteries.

Cancer and Crabs
Building multifunctional chiral building blocks from materials like D-glutamic acid opens up synthetic routes to natural products.

Room to Move
Cells behave differently when in 2 D environments, such as Petri dishes, to more natural, 3 D structures such as those in the human body.