Complex polycyclic structure with a highly oxygenated tricyclic core and a spiro-fused ring

First Total Synthesis of Havellockate

IUPAC Announced Top Ten Emerging Technologies in Chemistry 2022
Showcasing the value of chemistry and informing the general public how the chemical sciences contribute to society and sustainability

Subporphyrin Free Bases Synthesized
Ring-contracted porphyrins consisting of three pyrroles and three meso-carbons

Commercial Process for the Synthesis of Anti-Cancer Drug Sotorasib
Transformation of the established early synthesis route for sotorasib into an efficient large-scale process

Peri‐Functionalized Tetraazaperylenes
Polycyclic aromatic compounds show promise as strong emitters

Metal-Free C–H Borylation of Electron-Rich Alkenes
Path to borylated compounds which can be further functionalized in a one-pot approach

Catalyst‐Free C–F Activation of 3-Perfluoroalkyl Indoles
Reaction allows the introduction of a nucleophile in the perfluorinated side chain

Stopping Giardia Parasites in their Tracks
Antigiardial activity of novel guanidine compounds studied

Paper-Based Electronics
Customizable resistors, supercapacitors, and transistors on a single sheet of paper

Angewandte Chemie 43/2022: Highly Advantageous
Overview of the latest issue of Angewandte Chemie