Nuclear imaging techniques study the brain distribution of multiple sclerosis drugs with additional iodine
Author Archive for: Scott Williams (55)
A Drug Pipeline Going Dry
The number of effective anti-tuberculosis (TB) drugs continues to dwindle; can we find new agents for treating drug-resistant TB?
New Routes to IN Inhibition
HIV-1 integrase (IN) is an essential enzyme for HIV-1 replication: New routes to IN inhibition could overcome drug resistance
Finding Hidden Chirality
The importance of an often overlooked source of chirality, atropisomerism, depends upon the barriers to rotation
25 Years of HIV/AIDS Research
1985 was an important year in the history of HIV/AIDS research: a look at the past and future of HIV research
Two Birds, One Stone
Single drug that blocks NO production by inhibiting two different enzyme targets could reduce tumor growth
Replacing a Ring with a Ball
Asborin, the carbaborane-containing analogue of aspirin, holds promise as lead structure for aldo/keto reductase (AKR) inhibition
Easier Tubulysins: Delivered!
Delivery of tubulysin analogues using dendrimer conjugation technology promises efficacy without toxicity
Proteomic Approach
A proteomics approach to protein binding provides a pull-down menu for medicinal chemists
Pièce de Résistance!
Extremely potent compound against various multidrug-resistant HIV-1 variants developed