Direct [2 + 4] annulation of alkyl(phenyl)phosphinic chlorides and α,β-enones

Stereoselective Synthesis of δ-Phosphinolactones

Preparing Better Drugs from Paracetamol and Valproic Acid
Phosphonate derivatives of old drugs show greater potency with decreased toxicity

Cost-Efficient Upcycling of Polyurea Waste
Preparation of dynamic covalent poly(aminoketoenamide) networks from polyureas via vinylogous amides

Residue from Professional Dishwashers Could Harm the Gut
Alcohol ethoxylates found in rinse aids could disrupt the barrier integrity of intestinal lining

Merck Acquires Erbi Biosystems
Combining the technologies of Merck and the leading perfusion microbioreactor manufacturer enables rapid laboratory testing for bioprocess scale-up

Mario Markus Prize for Ludic Sciences Awarded for the First Time
Johann Ostmeyer, Christoph Schürmann, and Carsten Urbach honored for scientific work with a playful character

Alkene Hydroacylation with Triple Catalysis
Branched-selective hydroacylation uses cooperative photoredox, cobalt, and N-heterocyclic carbene catalysis

Searching for Christmas Presents?
Editors recommend science-themed holiday gift ideas

Total Synthesis of Foeniculoxin
Toxin produced by a fungus that causes disease in fennel plants

Angewandte Chemie 49/2022: Chemical Approaches
Overview of the latest issue of Angewandte Chemie