Forced oxidative mechanochemical degradation of active pharmaceutical ingredients

Ball Milling Used to Predict Degradation of Pharmaceutical Agents

Angewandte Chemie 45/2021: Direct Evidence
Overview of the latest issue of Angewandte Chemie

PFAS Levels in Organic Waste Used as Fertilizer
Lower levels of per- and polyfluoroalkyl substances (PFAS) found in livestock manures than in waste of urban origin

Methoxylation of Aryl Bromides
Copper-catalyzed cross-coupling reaction with 9-methoxy-9-borabicyclo[3.3.1]nonane (9-BBN-OMe)

Silver(III) Complexes with Unprecedented Structures
Trifluoromethyl groups stabilize silver in its highest oxidation state

Strained Al–Al Bond in a Three-Membered Ring
Dianionic aluminium analogue of an epoxide

The Chemical Bond: Failure of the Electronegativity Model
When atom size instead of electronegativity difference determines the trend in bond strength

Deoxyribozyme Catalyzes a Chemiluminescent Reaction
Programmable deoxyribozyme sensor detects oligonucleotides and produces light

Drug Candidate against Retinal Degeneration
Inhibitor of cGMP-dependent protein kinases prepared in sufficient amounts for further studies

Reductive Cross-Coupling Using Phosphonium Salts
Nickel-catalyzed reaction with allylic C–O bond electrophiles