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Biotechnology Journal

Engineering Concepts in Stem Cell Research

Published: 25 September 2017

Author(s): Karthikeyan Narayanan, Sachin Mishra, Satnam Singh, Ming Pei, Balazs Gulyas, Parasuraman Padmanabhan

The field of regenerative medicine integrates advancements made in stem cells, molecular biology, engineering, and clinical methodologies. Stem cells serve as a fundamental ingredient for therapeutic application in regenerative medicine. Apart from stem cells, engineering concepts have equally contributed to the success of stem cell based applications in improving human health. The purpose of various engineering...

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Chemistry - An Asian Journal

How a Transition‐Metal(II) Chloride Interacts with a Eutectic AlCl 3 ‐Based Ionic Liquid: Insights into the Speciation of the Electrolyte and Electrodeposition of Magnetic Materials

Published: 25 September 2017

Author(s): Giridhar Pulletikurthi, Bernd Weidenfeller, Andriy Borodin, Jan C. Namyslo, Frank Endres

Abstract Electrostatic interactions are characteristic of ionic liquids (ILs) and play a pivotal role in determining the formation of species when solutes are dissolved in them. The formation of new species/complexes has been investigated for certain ILs. However, such investigations have not yet focused on eutectic liquids, which are a promising class of ILs. These liquids (or liquid coordination complexes, LCCs) are rather new and...

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Biotechnology Journal

Synthetic Poly(Vinylalcohol)‐Based Membranes for Cartilage Surgery and Repair

Published: 25 September 2017

Author(s): Benjamin C. U. Tai, Chan Du, Shujun Gao, Andrew C. A. Wan

Cell‐based therapies for cartilage repair are continually being developed to treat osteoarthritis. The cells are either introduced directly by intra‐articular injection or via a cell‐seeded matrix scaffold. Here, poly(vinylalcohol)‐based membranes are developed to be used for mesenchymal stem cell implantation in cartilage repair procedures, having controllable physicochemical properties such as porosity, mechanical...

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Biotechnology Journal

Amine‐Mediated Enzymatic Carboxylation of Phenols Using CO 2 as Substrate Increases Equilibrium Conversions and Reaction Rates

Published: 25 September 2017

Author(s): Lorenzo Pesci, Pavel Gurikov, Andreas Liese, Selin Kara

A variety of strategies is applied to alleviate thermodynamic and kinetic limitations in biocatalytic carboxylation of metabolites in vivo. A key feature to consider in enzymatic carboxylations is the nature of the cosubstrate: CO2 or its hydrated form, bicarbonate. The substrate binding and activation mechanism determine what the actual carboxylation agent is. Dihydroxybenzoic acid (de)carboxylases catalyze the reversible...

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Biotechnology Journal

Transparent Substrates Prepared From Different Amorphous Polymers Can Directly Modulate Primary Human B cell functions

Published: 25 September 2017

Author(s): Toralf Roch, Stefanie Hahne, Karl Kratz, Nan Ma, Andreas Lendlein

Manipulation of B cell functions such as antibody and cytokine secretion, is of clinical and biotechnological interest and can be achieved by soluble ligands activating cell surface receptors. Alternatively, the exposure to suitable solid substrates would offer the possibility to transiently induced cell signaling, since the signaling is interrupted when the cells are removed from the substrate. Cell/substrate...

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Biotechnology Journal

Albumin‐Assisted Method Allows Assessment of Release of Hydrophobic Drugs From Nanocarriers

Published: 25 September 2017

Author(s): Dmitry Gil, Anastasia Frank‐Kamenetskii, John Barry, Vladimir Reukov, Yun Xiang, Arabinda Das, Abhay K. Varma, Mark S. Kindy, Naren L. Banik, Alexey Vertegel

Polymeric nanoparticles have been extensively studied as drug delivery vehicles both in vitro and in vivo for the last two decades. In vitro methods to assess drug release profiles usually utilize degradation of nanoparticles in aqueous medium, followed by the measurement of the concentration of the released drug. This method, however, is difficult to use for drugs that are poorly water soluble. In this study, a...

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Biotechnology Journal

Fetal Bone Marrow‐Derived Mesenchymal Stem/Stromal Cells Enhance Humanization and Bone Formation of BMP7 Loaded Scaffolds

Published: 25 September 2017

Author(s): Abbas Shafiee, Jeremy G. Baldwin, Jatin Patel, Boris M. Holzapfel, Nicholas M. Fisk, Kiarash Khosrotehrani, Dietmar W. Hutmacher

Tissue engineered constructs built with human cells capable of generating a bone‐like organ within the mouse have attracted considerable interest over the past decade. Here, we aimed to compare the utility of human mesenchymal stem/stromal cells (MSC) isolated from fetal term placenta (fPL‐MSC) and fetal first trimester bone marrow (fBM‐MSC) in a polycaprolactone scaffold/BMP7‐based model in nude mice. Furthermore,...

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Biotechnology Journal

Cell‐Surface Expression Levels Are Important for Fine‐Tuning the Performance of Receptor Tyrosine Kinase‐Based Signalobodies

Published: 25 September 2017

Author(s): Hideto Nakabayashi, Masahiro Kawahara, Teruyuki Nagamune

As receptor tyrosine kinases (RTKs) play important roles in cell‐fate control of various cell types, engineered RTKs that could respond to inexpensive ligands might drastically reduce the cost of producing desired cells for various applications in regenerative medicine. We developed several engineered RTKs named “signalobodies” in which the ligand‐recognition domain of RTKs is replaced by single‐chain Fv for enabling...

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Biotechnology Journal

Microheterogeneity of Recombinant Antibodies: Analytics and Functional Impact

Published: 25 September 2017

Author(s): Beate Beyer, Manfred Schuster, Alois Jungbauer, Nico Lingg

Antibodies are typical examples of biopharmaceuticals which are composed of numerous, almost infinite numbers of potential molecular entities called variants or isoforms, which constitute the microheterogeneity of these molecules. These variants are generated during biosynthesis by so‐called posttranslational modification, during purification or upon storage. The variants differ in biological properties such as...

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Biotechnology Journal

Identification and Engineering of Post‐PKS Modification Bottlenecks for Ansamitocin P‐3 Titer Improvement in Actinosynnema pretiosum subsp . pretiosum ATCC 31280

Published: 25 September 2017

Author(s): Xinjuan Ning, Xinran Wang, Yuanting Wu, Qianjin Kang, Linquan Bai

The type‐I polyketide ansamitocin P‐3 (AP‐3) is a potent antitumor agent. Its production is most likely hampered by the required multiple substrate supplies and complicated post‐PKS modifications in Actinosynnema pretiosum subsp. pretiosum ATCC 31280. For titer improvement, gene ansa30, encoding for a glycosyltransferase competing for the N‐demethyl‐AP‐3 (PND‐3) intermediate for AP‐3 biosynthesis, was initially inactivated. In the mutant NXJ‐22,...

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Most-accessed articles from each ChemPubSoc Europe, ACES, and GDCh journal

July 2017


Xinxing Zhang, Gaoxiang Liu, Sandra Ciborowski, Kit Bowen
Stabilizing Otherwise Unstable Anions with Halogen Bonding [Communication]
Angew. Chem. Int. Ed. 2017, vol. 56, p. 9897

Jonathan Okerblom, Ajit Varki
Biochemical, Cellular, Physiological, and Pathological Consequences of Human Loss of N-Glycolylneuraminic Acid [Review]
ChemBioChem 2017, vol. 18, p. 1155

Hélène Olivier-Bourbigou, Céline Chizallet, Franck Dumeignil, Pascal Fongarland, Christophe Geantet, Pascal Granger, Franck Launay, Axel Löfberg, Pascale Massiani, Françoise Maugé, Armelle Ouali, Anne-Cécile Roger, Yves Schuurman, Nathalie Tanchoux, Denis Uzio, François Jérôme, Daniel Duprez, Catherine Pinel
The Pivotal Role of Catalysis in France: Selected Examples of Recent Advances and Future Prospects. [Review]
ChemCatChem 2017, vol. 9, p. 2029

Klaus Roth, Elisabeth Vaupel
Von Insekten, Chrysanthemen und Menschen [Artikel]
Chem. Unserer Zeit 2017, vol. 51, p. 162

Balaram Mukhopadhyay, Rituparna Das
Chemical O-Glycosylations: An Overview [Review]
ChemistryOpen 2016, vol. 5, p. 401

Sigma Hashimoto, Takahiro Iwamoto, Daisuke Kurachi, Eiichi Kayahara, Shigeru Yamago
Shortest Double-Walled Carbon Nanotubes Composed of Cycloparaphenylenes [Communication]
ChemPlusChem 2017, vol. 82, p. 1015

Miaofang Chi, Harry M. Meyer, Zili Wu, Liangbo Liang, Peter V. Bonnesen, Dale K. Hensley, Rui Peng, Yang Song, Cheng Ma, Bobby G. Sumpter, Adam J. Rondinone
High-Selectivity Electrochemical Conversion of CO2 to Ethanol using a Copper Nanoparticle/N-Doped Graphene Electrode [Full Paper]
ChemistrySelect 2016, vol. 1, p. 6055

Ekkehard Schwab, Sebastian Schiebahn, Georg Schaub, Martin Reuter, Konstantin Räuchle, Ludolf Plass, Marcell Peuckert, Anja Metzelthin, Falko Mahlendorf, Wolfram Koch, Renate Hoer, Angelika Heinzel, Sigmar Bräuninger, Martin Bertau, Christian Beilmann, Florian Ausfelder, Ferdi Schüth, Detlef Stolten, Gisa Teßmer, Kurt Wagemann, Karl-Friedrich Ziegahn
Energiespeicherung als Element einer sicheren Energieversorgung [Übersichtsbeitrag]
Chem. Ing. Tech. 2015, vol. 87, p. 17

Abas Mohsenzadeh, Akram Zamani, Mohammad J. Taherzadeh
Bioethylene Production from Ethanol: A Review and Techno-economical Evaluation [Review]
ChemBioEng Rev. 2017, vol. 4, p. 75

Marc T. M. Koper, Hasan Yılmaz, Ruud Kortlever, Recep Kas, Guido Mul
Manipulating the Hydrocarbon Selectivity of Copper Nanoparticles in CO2 Electroreduction by Process Conditions [Communication]
ChemElectroChem 2015, vol. 2, p. 354

Liming Dai, Xinliang Feng, Zhongfan Liu, Hua Zhang
Two-Dimensional Materials: A Powerful Platform for Energy Applications [Editorial]
ChemNanoMat 2017, vol. 3, p. 338

Ralf Haiges, Piyush Deokar, Monica Vasiliu, Trent H. Stein, David A. Dixon, Karl O. Christe
Cover Picture: Preparation and Characterization of Group 13 Cyanides (Chem. Eur. J. 38/2017) [Cover Picture]
Chem. Eur. J. 2017, vol. 23, p. 8989

Yilong Yang, Songcan Wang, Yongli Li, Jinshu Wang, Lianzhou Wang
Strategies for Efficient Solar Water Splitting Using Carbon Nitride [Focus Review]
Chem. Asian J. 2017, vol. 12, p. 1421

Yunhe Jin, Hua Fu
Visible-Light Photoredox Decarboxylative Couplings [Focus Review]
Asian J. Org. Chem. 2017, vol. 6, p. 368

Edmond Differding
The Drug Discovery and Development Industry in India-Two Decades of Proprietary Small-Molecule R&D [Review]
ChemMedChem 2017, vol. 12, p. 786

Sergey Akbulatov, Roman Boulatov
Experimental Polymer Mechanochemistry and its Interpretational Frameworks [Review]
ChemPhysChem 2017, vol. 18, p. 1422

Jia-Rong Chen, Dong-Mei Yan, Qiang Wei, Wen-Jing Xiao
Photocascade Catalysis: A New Strategy for Cascade Reactions [Concept]
ChemPhotoChem 2017, vol. 1, p. 148

Hirotaka Koga, Naoko Namba, Tsukasa Takahashi, Masaya Nogi, Yuta Nishina
Renewable Wood Pulp Paper Reactor with Hierarchical Micro/Nanopores for Continuous-Flow Nanocatalysis [Communication]
ChemSusChem 2017, vol. 10, p. 2560

Ross J. Marshall, Ross S. Forgan
Postsynthetic Modification of Zirconium Metal-Organic Frameworks [Microreview]
Eur. J. Inorg. Chem. 2016, p. 4310

Gregory J. P. Perry, Igor Larrosa
Recent Progress in Decarboxylative Oxidative Cross-Coupling for Biaryl Synthesis [Microreview]
Eur. J. Org. Chem. 2017, p. 3517

MATLAB für Dummies von Jim Sizemore und John Paul Mueller [Buchbesprechung]
Lebensmittelchemie 2017, vol. 71, p. 32

Reinhard Zellner
Die Fakten und ihre Wahrnehmung [Bildung & Gesellschaft]
Nachr. Chem. 2017, vol. 65, p. 662

Jana Thomas, Sabine Struckmeier, Bernhard F. Sieve
„Molekulares Sieben 2.0“ - vom Kontinuum zum Diskontinuum mit molekularer Küche [Das Experiment]
CHEMKON 2017, vol. 24, p. 142

Sarah Millar
Tips and Tricks for the Lab: Column Choices
ChemViews Magazine 2012.

Most cited articles from each ChemPubSoc Europe, ACES, and GDCh journal



Shoujun Zhu, Qingnan Meng, Lei Wang, Junhu Zhang, Yubin Song, Han Jin, Kai Zhang, Hongchen Sun, Haiyu Wang, Bai Yang
Highly Photoluminescent Carbon Dots for Multicolor Patterning, Sensors, and Bioimaging
Angew. Chem. Int. Ed. 2013, vol. 52, pp. 3953–3957

Balayeshwanth R. Vummidi, Jawad Alzeer, Nathan W. Luedtke
Fluorescent Probes for G-Quadruplex Structures [Review]
ChemBioChem 2013, vol. 14, pp. 540–558

Zhi-Yuan Gu, Jihye Park, Aaron Raiff, Zhangwen Wei, Hong-Cai Zhou
Metal–Organic Frameworks as Biomimetic Catalysts [Minireview]
ChemCatChem 2014, vol. 6, pp. 67–75

Anthony J. Arduengo, Roland Krafczyk
Auf der Suche nach Stabilen Carbenen [Organische Chemie]
Chem. Unserer Zeit 1998, vol. 32, pp. 6–14

Marc Steinmetz, Stefan Grimme
Benchmark Study of the Performance of Density Functional Theory for Bond Activations with (Ni,Pd)-Based Transition-Metal Catalysts [Full Paper]
ChemistryOpen 2013, vol. 2, pp. 115–124

Philipp Scharf, Jens Müller
Nucleic Acids With Metal-Mediated Base Pairs and Their Applications [Review]
ChemPlusChem 2013, vol. 78, pp. 20–34

Philipp Kaiser, Rajabhau Bajirao Unde, Christoph Kern, Andreas Jess
Production of Liquid Hydrocarbons with CO2 as Carbon Source based on Reverse Water-Gas Shift and Fischer-Tropsch Synthesis [Research Article]
Chem. Ing. Tech. 2013, vol. 85, pp. 489–499

Xiaosi Zhou, Yu-Guo Guo
Highly Disordered Carbon as a Superior Anode Material for Room-Temperature Sodium-Ion Batteries [Communication]
ChemElectroChem 2014, vol. 1, pp. 83–86

Chuanxi Wang, Zhenzhu Xu, Chi Zhang
Polyethyleneimine-Functionalized Fluorescent Carbon Dots: Water Stability, pH Sensing, and Cellular Imaging [Full Paper]
ChemNanoMat 2015, vol. 1, pp. 122–127

Konggang Qu, Jiasi Wang, Jinsong Ren, Xiaogang Qu
Carbon Dots Prepared by Hydrothermal Treatment of Dopamine as an Effective Fluorescent Sensing Platform for the Label-Free Detection of Iron(III) Ions and Dopamine [Full Paper]
Chem. Eur. J. 2013, vol. 19, pp. 7243–7249

Yinuo Wu, Jun Wang, Fei Mao, Fuk Yee Kwong
Palladium-Catalyzed Cross-Dehydrogenative Functionalization of C(sp2)–H Bonds [Focus Review]
Chem. Asian J. 2014, vol. 9, pp. 26–47

Naohiko Yoshikai, Ye Wei
Synthesis of Pyrroles, Indoles, and Carbazoles through Transition-Metal-Catalyzed C–H Functionalization [Review]
Asian J. Org. Chem. 2013, vol. 2, pp. 466–478

Lluís Ballell, Robert H. Bates, Rob J. Young, Daniel Alvarez-Gomez, Emilio Alvarez-Ruiz, Vanessa Barroso, Delia Blanco, Benigno Crespo, Jaime Escribano, Rubén González, Sonia Lozano, Sophie Huss, Angel Santos-Villarejo, José Julio Martín-Plaza, Alfonso Mendoza, María José Rebollo-Lopez, Modesto Remuiñan-Blanco, José Luis Lavandera, Esther Pérez-Herran, Francisco Javier Gamo-Benito, José Francisco García-Bustos, David Barros, Julia P. Castro, Nicholas Cammack
Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis [Full Paper]
ChemMedChem 2013, vol. 8, pp. 313–321

Peter Politzer, Jane S. Murray
Halogen Bonding: An Interim Discussion [Review]
ChemPhysChem 2013, vol. 14, pp. 278–294

Volker Hessel, Dana Kralisch, Norbert Kockmann, Timothy Noël, Qi Wang
Novel Process Windows for Enabling, Accelerating, and Uplifting Flow Chemistry [Review]
ChemSusChem 2013, vol. 6, pp. 746–789

Helena J. Shepherd, Gábor Molnár, William Nicolazzi, Lionel Salmon, Azzedine Bousseksou
Spin Crossover at the Nanometre Scale [Microreview]
Eur. J. Inorg. Chem. 2013, pp. 653–661

Junichiro Yamaguchi, Kei Muto, Kenichiro Itami
Recent Progress in Nickel-Catalyzed Biaryl Coupling [Microreview]
Eur. J. Org. Chem. 2013, pp. 19–30

David Schweinfurth, Naina Deibel, Fritz Weisser, Biprajit Sarkar
Mit Klick zu neuen Liganden [Magazin]
Nachr. Chem. 2011, vol. 59, pp. 937–941
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