Hamster trial finds live-attenuated vaccine candidate that is administered nasally to be more effective than conventional vaccines

Promising Results for Nasal COVID-19 Vaccine in Hamster Trial

Advancing Development of Personalized Antibody-Drug Conjugate Therapies for Solid Tumors
BioNTech has obtained exclusive licenses from DualityBio for two investigational antibody-drug conjugate assets that target a wide range of human cancers

Convergent Total Synthesis of (+)-Ineleganolide
Natural product with a highly oxidized framework and a central seven-membered ring

Mn-Catalyzed Allylation of Benzoates
Simple manganese catalyst for ortho-C–H allylations, which can be combined with a decarboxylation to access allylarenes

Triazole-Substituted Ethisterones as Anticancer Compounds
Single-step syntheses of derivatives with promising cytotoxic activities

Highly Strained Antiaromatic Metallacycle Isolated
Smallest angle of a metal vinylidene within a six-membered ring reported so far

Use of Artificial Intelligence in Drug Development
WACKER, CordenPharma, Munich’s Ludwig Maximilian University (LMU) and the Humboldt University of Berlin train machine learning algorithm to make RNA drugs

Aerobic C–C Bond Cleavage of Tertiary Allylic Alcohols
Co-catalyzed hydrogen atom transfer process gives ketones

Ensuring Ethical Standards in Emerging Technologies
Bayer establishes Bioethics Council comprising of renowned international experts

Electrochemical Reduction of Diarylketones and Aryl Alkenes
Using acetonitrile as the main proton donor in a mixed-solvent electrochemical reduction system