22nd Annual Discovery on Target

22nd Annual Discovery on Target

Covering advances in targets, technologies, and target validation strategies for the development of novel therapeutic agents

First Total Synthesis of Pepluacetal

First Total Synthesis of Pepluacetal

Route relying on a Wolff rearrangement/lactonization cascade, a ring-closing metathesis/cyclopropanation sequence, and a late-stage transannular carbenoid insertion