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Journal of Applied Toxicology

Intermittent dosing of the transforming growth factor beta receptor 1 inhibitor, BMS‐986260, mitigates class‐based cardiovascular toxicity in dogs but not rats

Published: 15 February 2020

Author(s): Gene E. Schulze, Michael J. Graziano, Courtni Newsome, Karen Augustine‐Rauch, Melvin R. White, Gregory D. Rak

Abstract Small‐molecule inhibitors of transforming growth factor beta receptor 1 (TGFβRI) have a history of significant class‐based toxicities (eg, cardiac valvulopathy) in preclinical species that have limited their development as new medicines. Nevertheless, some TGFβRI inhibitors have entered into clinical trials using intermittent‐dosing schedules and exposure limits in an attempt to avoid these toxicities. This report describes the toxicity profile of the small‐molecule TGFβRI inhibitor,...

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Phytotherapy Research

Natural polyphenols in preclinical models of epilepsy

Published: 15 February 2020

Author(s): Ashish Dhir

Natural polyphenols are being tested both in preclinical and clinical settings for the treatment of different neurological disorders. The article describes the outcome of three polyphenols, resveratrol, epigallocatechin gallate, and quercetin, in preclinical animal models of epilepsy (both acute and chronic) and epileptogenesis. In theory, the antioxidant and neuroprotective properties of these natural polyphenols might be valuable in the management of acute seizures and the prevention of...

Biotechnology and Bioengineering

A dynamic model linking cell growth to intracellular metabolism and extracellular by‐product accumulation

Published: 15 February 2020

Author(s): Udo Reichl, Volker Sandig, Yvonne Genzel, Alexander G. Rath, João R. C. Ramos

Abstract Mathematical modeling of animal cell growth and metabolism is essential for the understanding and improvement of the production of biopharmaceuticals. Models can explain the dynamic behavior of cell growth and product formation, support the identification of the most relevant parameters for process design, and significantly reduce the number of experiments to be performed for process optimization. Few dynamic models have been established that describe both extracellular and...

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Journal of Computational Chemistry

Quantitative decomposition of resonance‐assisted hydrogen bond energy in β‐diketones into resonance and hydrogen bonding (π‐ and σ‐) components using molecular tailoring and function‐based approaches

Published: 15 February 2020

Author(s): Andrei V. Afonin, Alexander V. Vashchenko

Abstract Using the molecular tailoring and function‐based approaches allows one to divide the energy of the O─H⋯O═C resonance‐assisted hydrogen bond in a series of the β‐diketones into resonance and hydrogen bonding components. The magnitude of the resonance component is assessed as about 6 kcal mol−1. This value increases by ca. 1 kcal mol−1 on going from the weak to strong resonance‐assisted hydrogen bonding. The magnitude of the hydrogen bonding component varies in the wide range from 2 to...

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British Journal of Pharmacology

Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties

Published: 15 February 2020

Author(s): Thaise Boeing, Priscila Souza, Silvia Speca, Lincon Bordignon Somensi, Luisa Nathália Bolda Mariano, Benhur Judah Cury, Mariana Ferreira dos Anjos, Nara Lins Meira Quintão, Laurent Dubuqoy, Pierre Desreumax, Luisa Mota Silva, Sérgio Faloni Andrade

Background and Purpose Intestinal mucositis refers to mucosal damage caused by cancer treatment, and irinotecan is one of the agents most associated with this condition. Focusing on the development of alternatives to prevent this important adverse effect, we evaluated the activity of the flavonoid luteolin, which has never been tested for this purpose despite its biological potential. Experimental Approach The effects of luteolin were examined on irinotecan‐induced intestinal mucositis in...

British Journal of Pharmacology

Protein kinase A facilitates relaxation of mouse ileum via phosphorylation of neuronal nitric oxide synthase

Published: 15 February 2020

Author(s): Damian D. Guerra, Rachael Bok, Ramón A. Lorca, K. Joseph Hurt

Background and Purpose The enteric neurotransmitter nitric oxide (NO) regulates gastrointestinal motility by relaxing smooth muscle. Pharmacological cAMP induction also relaxes gastrointestinal smooth muscle, but it is uncertain whether cAMP augments or suppresses enteric NO signalling. In other organ systems, cAMP can increase neuronal NO production by stimulating protein kinase A (PKA) to phosphorylate neuronal NOS (nNOS) Serine‐1412 (S1412). We hypothesized that cAMP also increases nNOS...

British Journal of Pharmacology

Opioid presynaptic disinhibition of the midbrain periaqueductal grey descending analgesic pathway

Published: 15 February 2020

Author(s): Benjamin K. Lau, Bryony L. Winters, Christopher W. Vaughan

Background and Purpose The midbrain periaqueductal grey (PAG) plays a central role in modulating pain through a descending pathway that projects indirectly to the spinal cord via the rostroventral medial medulla (RVM). While opioids are potent analgesics that target the PAG, their cellular actions on descending projection neurons are unclear. Experimental Approach Patch clamp recordings in voltage‐ and current‐clamp mode were made from acutely prepared PAG slices from animals that received...

British Journal of Pharmacology

Novel M2‐selective, Gi‐biased agonists of muscarinic acetylcholine receptors

Published: 15 February 2020

Author(s): Alena Randáková, Dominik Nelic, Dana Ungerová, Peter Nwokoye, Qiwen Su, Vladimír Doležal, Esam E. El‐Fakahany, John Boulos, Jan Jakubík

Background and Purpose More than 30% of currently marketed medications act via GPCRs. Thus, GPCRs represent one of the most important pharmacotherapeutic targets. In contrast to traditional agonists activating multiple signalling pathways, agonists activating a single signalling pathway represent a new generation of drugs with increased specificity and fewer adverse effects. Experimental Approach We have synthesized novel agonists of muscarinic ACh receptors and tested their binding and...

Biotechnology and Bioengineering

Making sense of parameter estimation and model simulation in bioprocesses

Published: 15 February 2020

Author(s): M. Constanza Sadino‐Riquelme, José Rivas, David Jeison, Robert E. Hayes, Andrés Donoso‐Bravo

Abstract Most articles that report fitted parameters for kinetic models do not include meaningful statistical information. This study demonstrates the importance of reporting a complete statistical analysis and shows a methodology to perform it, using functionalities implemented in computational tools. As an example, alginate production is studied in a batch stirred‐tank fermenter and modeled using the kinetic model proposed by Klimek and Ollis (1980). The model parameters and their 95%...

Journal of Biochemical and Molecular Toxicology

Dimethyl fumarate protects thioacetamide‐induced liver damage in rats: Studies on Nrf2, NLRP3, and NF‐κB

Published: 15 February 2020

Author(s): Durgesh K. Dwivedi, Gopabandhu Jena, Vinod Kumar

Abstract The present study was designed to investigate the hepatoprotective potential of dimethyl fumarate (DMF) against thioacetamide (TAA)‐induced liver damage. Wistar rats were treated with DMF (12.5, 25, and 50 mg/kg/day, orally) and TAA (200 mg/kg intraperitoneally, every third day) for 6 consecutive weeks. TAA exposure significantly reduced body weight, increased liver weight and index, and intervention with DMF did not ameliorate these parameters. DMF treatment significantly restored...

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Most-accessed articles from each ChemPubSoc Europe, ACES, and GDCh journal

December 2019


	Duanyang Kong, Patrick J. Moon, Odey Bsharat, Rylan J. Lundgren Direct Catalytic Decarboxylative Amination of Aryl Acetic Acids [Research Article] Angew. Chem. Int. Ed. 2020, vol. 59, no. 3, p. 1313

	Bing Liu, Lihui He, Liping Wang, Tao Li, Changcheng Li, Huayi Liu, Yunzi Luo, Rui Bao Protein Crystallography and Site-Direct Mutagenesis Analysis of the Poly(ethylene terephthalate) Hydrolase PETase from Ideonella sakaiensis [Communication] ChemBioChem 2018, vol. 19, no. 14, p. 1471

	Isabela C. Man, Hai-Yan Su, Federico Calle-Vallejo, Heine A. Hansen, José I. Martínez, Nilay G. Inoglu, John Kitchin, Thomas F. Jaramillo, Jens K. Nørskov, Jan Rossmeisl Universality in Oxygen Evolution Electrocatalysis on Oxide Surfaces [Full Paper] ChemCatChem 2011, vol. 3, no. 7, p. 1159

	Wolfgang Pfeiffer, Van Than Nguyen, Jan Neumann, Dirk Awe, Jens Tränckner Operation and Control of a Full-Scale Biogas Plant Treating Wastewater from the Cleaning of Car Tanks [Research Article] Chem. Eng. Technol. 2020, vol. 43, no. 1, p. 84

	Dieter Wöhrle Kunststoffe [Artikel] Chem. Unserer Zeit 2019, vol. 53, no. 1, p. 50

	Luling Wu, Xue Tian, Hai-Hao Han, Jie Wang, Robin R. Groleau, Paramabhorn Tosuwan, Boontana Wannalerse, Adam C. Sedgwick, Steven D. Bull, Xiao-Peng He, Tony D. James A Simple Near-Infrared Fluorescent Probe for the Detection of Peroxynitrite [Communication] ChemistryOpen 2019, vol. 8, no. 12, p. 1407

	Daewoo Han, Andrew J. Steckl Coaxial Electrospinning Formation of Complex Polymer Fibers and their Applications [Review] ChemPlusChem 2019, vol. 84, no. 10, p. 1453

	Miaofang Chi, Harry M. Meyer, Zili Wu, Liangbo Liang, Peter V. Bonnesen, Dale K. Hensley, Rui Peng, Yang Song, Cheng Ma, Bobby G. Sumpter, Adam J. Rondinone High-Selectivity Electrochemical Conversion of CO₂ to Ethanol using a Copper Nanoparticle/N-Doped Graphene Electrode [Full Paper] ChemistrySelect 2016, vol. 1, no. 19, p. 6055

	Ekkehard Schwab, Sebastian Schiebahn, Georg Schaub, Martin Reuter, Konstantin Räuchle, Ludolf Plass, Marcell Peuckert, Anja Metzelthin, Falko Mahlendorf, Wolfram Koch, Renate Hoer, Angelika Heinzel, Sigmar Bräuninger, Martin Bertau, Christian Beilmann, Florian Ausfelder, Ferdi Schüth, Detlef Stolten, Gisa Teßmer, Kurt Wagemann, Karl-Friedrich Ziegahn Energiespeicherung als Element einer sicheren Energieversorgung [Übersichtsbeitrag] Chem. Ing. Tech. 2015, vol. 87, no. 1-2, p. 17

	Abas Mohsenzadeh, Akram Zamani, Mohammad J. Taherzadeh Bioethylene Production from Ethanol: A Review and Techno-economical Evaluation [Review] ChemBioEng Rev. 2017, vol. 4, no. 2, p. 75

	Lucia Mazzapioda, Carmelo Lo Vecchio, Annalisa Paolone, Antonino Salvatore Aricò, Vincenzo Baglio, Maria Assunta Navarra Enhancing Oxygen Reduction Reaction Catalytic Activity Using a Sub-Stoichiometric CaTiO_3−δ Additive [Cover Profile] ChemElectrochem 2019, vol. 6, no. 24, p. 5910

	S. Ghosh, B. Pradhan Lead-Free Metal Halide Perovskite Nanocrystals: Challenges, Applications, and Future Aspects [Minireview] ChemNanoMat 2019, vol. 5, no. 3, p. 300

	Frank Tabellion, Christoph Peters, Uwe Fischbeck, Manfred Regitz, Fritz Preuss Imidovanadium(V) Complexes as Reaction Partners for Kinetically Stabilized Phosphaalkynes: Synthesis of 1,2,4‐Azaphosphavanada(V)‐cyclobutenes, 1,3,5‐Triphosphabenzenes, and 1H‐1,2,4‐Azadiphospholes [Organophosphorus Compounds, Part 148 : Full Paper] Chem. Eur. J. 2000, vol. 6, no. 24, p. 4558

	Byunghyuck Jung, Jungkyu K. Lee, Jungnam Kim, Eunhye K. Kang, Sang Yeong Han, Hee-Yoon Lee, Insung S. Choi Synthetic Strategies for (−)-Cannabidiol and Its Structural Analogs [Minireview] Chem. Asian J. 2019, vol. 14, no. 21, p. 3749

	Arun K. Sinha, Danish Equbal Thiol−Ene Reaction: Synthetic Aspects and Mechanistic Studies of an Anti-Markovnikov-Selective Hydrothiolation of Olefins [Focus Review] Asian J. Org. Chem. 2019, vol. 8, no. 1, p. 32

	Avick Kumar Ghosh, Indranil Samanta, Anushree Mondal, Wenshe Ray Liu Covalent Inhibition in Drug Discovery [Review] ChemMedChem 2019, vol. 14, no. 9, p. 889

	Andrea Álvarez, Marta Borges, Juan José Corral-Pérez, Joan Giner Olcina, Lingjun Hu, Damien Cornu, Rui Huang, Dragos Stoian, Atsushi Urakawa CO₂ Activation over Catalytic Surfaces [Concept] ChemPhysChem 2017, vol. 18, no. 22, p. 3135

	Matthias Freitag, Nadja Möller, Andreas Rühling, Cristian A. Strassert, Bart Jan Ravoo, Frank Glorius Photocatalysis in the Dark: Near-Infrared Light Driven Photoredox Catalysis by an Upconversion Nanoparticle/Photocatalyst System [Communication] ChemPhotoChem 2019, vol. 3, no. 1, p. 24

	Mingshuai Ma, Lin Dai, Chuanling Si, Lanfeng Hui, Zhong Liu, Yonghao Ni Front Cover: A Facile Preparation of Super Long-Term Stable Lignin Nanoparticles from Black Liquor (ChemSusChem 24/2019) [Cover Picture] ChemSusChem 2019, vol. 12, no. 24, p. 5213

	Stephen A. Matlin, Goverdhan Mehta, Henning Hopf, Alain Krief The Periodic Table of the Chemical Elements and Sustainable Development [Essay] Eur. J. Inorg. Chem. 2019, p. 4170

	Luca Capaldo, Davide Ravelli Hydrogen Atom Transfer (HAT): A Versatile Strategy for Substrate Activation in Photocatalyzed Organic Synthesis [Microreview] Eur. J. Org. Chem. 2017, p. 2056

	Cover Picture Lebensmittelchemie 6/2019 [Cover Picture] Lebensmittelchemie 2019, vol. 73, no. 6

	Elementerätsel 1 [Wissenschaft + Forschung] Nachr. Chem. 2019, vol. 67, no. 12, p. 40

	Schüleraufgabe: CHEMKON 2/2017 [Schüleraufgabe] CHEMKON 2017, vol. 24, no. 2, p. 91

	Zheng Ma, Douglas R. MacFarlane, Mega Kar Mg Cathode Materials and Electrolytes for Rechargeable Mg Batteries: A Review [Minireview] Batteries & Supercaps 2019, vol. 2, no. 2, p. 115

	Catharina Goedecke Why Does Iodine Turn Starch Blue? ChemViews Magazine 2016

Most cited articles from each ChemPubSoc Europe, ACES, and GDCh journal

2017


	Eric J. Popczun, Carlos G. Read, Christopher W. Roske, Nathan S. Lewis, Raymond E. Schaak Highly Active Electrocatalysis of the Hydrogen Evolution Reaction by Cobalt Phosphide Nanoparticles Angew. Chem. Int. Ed. 2014, vol. 53, pp. 5427–5430

	Philippe Compain, Anne Bodlenner The Multivalent Effect in Glycosidase Inhibition: A New, Rapidly Emerging Topic in Glycoscience [Minireview] ChemBioChem 2014, vol. 15, pp. 1239–1251

	Zhi-Yuan Gu, Jihye Park, Aaron Raiff, Zhangwen Wei, Hong-Cai Zhou Metal–Organic Frameworks as Biomimetic Catalysts [Minireview] ChemCatChem 2014, vol. 6, pp. 67–75

	Anthony J. Arduengo, Roland Krafczyk Auf der Suche nach Stabilen Carbenen [Organische Chemie] Chem. Unserer Zeit 1998, vol. 32, pp. 6–14

	Félix Sancenón, Lluís Pascual, Mar Oroval, Elena Aznar, Ramón Martínez-Máñez Gated Silica Mesoporous Materials in Sensing Applications [Review] ChemistryOpen 2015, vol. 4, pp. 418–437

	Jun Pu, Tingting Wang, Haiyang Wang, Yao Tong, Chenchen Lu, Wei Kong, Zhenghua Wang Direct Growth of NiCo₂S₄ Nanotube Arrays on Nickel Foam as High-Performance Binder-Free Electrodes for Supercapacitors [Full Paper] ChemPlusChem 2014, vol. 79, pp. 577–583

	Francisco Trespalacios, Ignacio E. Grossmann Review of Mixed-Integer Nonlinear and Generalized Disjunctive Programming Methods [Review] Chemie Ingenieur Technik 2014, vol. 86, pp. 991–1012

	Xiaosi Zhou, Yu-Guo Guo Highly Disordered Carbon as a Superior Anode Material for Room-Temperature Sodium-Ion Batteries [Communication] ChemElectroChem 2014, vol. 1, pp. 83–86

	Chuanxi Wang, Zhenzhu Xu, Chi Zhang Polyethyleneimine-Functionalized Fluorescent Carbon Dots: Water Stability, pH Sensing, and Cellular Imaging [Full Paper] ChemNanoMat 2015, vol. 1, pp. 122–127

	Matthew N. Hopkinson, Basudev Sahoo, Jun-Long Li, Frank Glorius Dual Catalysis Sees the Light: Combining Photoredox with Organo-, Acid, and Transition-Metal Catalysis [Minireview] Chemistry – A European Journal 2014, vol. 20, pp. 3874–3886

	Yinuo Wu, Jun Wang, Fei Mao, Fuk Yee Kwong Palladium-Catalyzed Cross-Dehydrogenative Functionalization of C(sp²)–H Bonds [Focus Review] Chemistry – An Asian Journal 2014, vol. 9, pp. 26–47

	Derong Cao, Herbert Meier Pillar[n]arenes—a Novel, Highly Promising Class of Macrocyclic Host Molecules [Focus Review] Asian Journal of Organic Chemistry 2014, vol. 3, pp. 244–262

	Daniel Gallenkamp, Kathy A. Gelato, Bernard Haendler, Hilmar Weinmann Bromodomains and Their Pharmacological Inhibitors [Review] ChemMedChem 2014, vol. 9, pp. 438–464

	Antonio Bauzá, Tiddo J. Mooibroek, Antonio Frontera The Bright Future of Unconventional σ/π-Hole Interactions [Review] ChemPhysChem 2015, vol. 16, pp. 2496–2517

	Ksenia S. Egorova, Valentine P. Ananikov Toxicity of Ionic Liquids: Eco(cyto)activity as Complicated, but Unavoidable Parameter for Task-Specific Optimization [Review] ChemSusChem 2014, vol. 7, pp. 336–360

	Shunichi Fukuzumi, Dachao Hong Homogeneous versus Heterogeneous Catalysts in Water Oxidation [Microreview] Eur. J. Inorg. Chem. 2014, pp. 645–659

	Fabien Toulgoat, Sébastien Alazet, Thierry Billard Direct Trifluoromethylthiolation Reactions: The “Renaissance” of an Old Concept [Microreview] Eur. J. Org. Chem. 2014, pp. 2415–2428

	David Schweinfurth, Naina Deibel, Fritz Weisser, Biprajit Sarkar Mit Klick zu neuen Liganden [Magazin] Nachr. Chem. 2011, vol. 59, pp. 937–941