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Chemical Biology & Drug Design

Fragment‐ and negative image‐based screening of phosphodiesterase 10A inhibitors

Published: 19 July 2019

Author(s): Elmeri M. Jokinen, Pekka A. Postila, Mira Ahinko, Sanna Niinivehmas, Olli T. Pentikäinen

Abstract A novel virtual screening methodology called fragment‐ and negative image‐based (F‐NiB) screening is introduced and tested experimentally using phosphodiesterase 10A (PDE10A) as a case study. Potent PDE10A‐specific small‐molecule inhibitors are actively sought after for their antipsychotic and neuroprotective effects. The F‐NiB combines features from both fragment‐based drug discovery and negative image‐based (NIB) screening methodologies to facilitate rational drug discovery. The...

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British Journal of Pharmacology

Neutrophil extracellular trap‐microparticle complexes trigger neutrophil recruitment via high‐mobility group protein 1 (HMGB1)‐toll‐like receptors(TLR2)/TLR4 signalling

Published: 19 July 2019

Author(s): Yongzhi Wang, Feifei Du, Avin Hawez, Matthias Mörgelin, Henrik Thorlacius

Background and Purpose Recent data suggest that neutrophil extracellular traps (NETs) form aggregates with microparticles (MPs) upon activation of neutrophils although the functional role of NET‐MP complexes remain elusive. The objective of this study was to examine the role of NET‐MP aggregates in leukocyte recruitment in vivo. Experimental Approach PMA stimulation of murine bone marrow neutrophils generated NET‐MP complexes and pretreatment with caspase and calpain inhibitors resulted in the...

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British Journal of Pharmacology

Inhibition of polycomb repressor complex 2 ameliorates neointimal hyperplasia by suppressing trimethylation of H3K27 in vascular smooth muscle cells

Published: 19 July 2019

Author(s): Jing Liang, Qi Li, Wenbin Cai, Xuejiao Zhang, Bing Yang, Xin Li, Shuai Jiang, Shanshan Tian, Kai Zhang, Hao Song, Ding Ai, Xu Zhang, Chunjiong Wang, Yi Zhu

Background and Purpose The increased proliferation and migration of vascular smooth muscle cells (VSMCs) after arterial injury contributes greatly to the pathogenesis of neointimal hyperplasia. As a major component of epigenetics, histone methylation plays an important role in several cardiovascular diseases. However, its role in restenosis is still unclear. Experimental Approach Human aortic VSMCs were challenged with PDGF‐BB, and total histones were extracted and analysed by HPLC/MS. For the...

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British Journal of Clinical Pharmacology

A systematic review of cannabidiol dosing in clinical populations

Published: 19 July 2019

Author(s): S.A. Millar, N.L. Stone, Z.D. Bellman, A.S. Yates, T.J. England, S.E. O'Sullivan

Aims Cannabidiol (CBD) is a cannabis‐derived medicinal product with potential application in a wide‐variety of contexts; however, its effective dose in different disease states remains unclear. This review aimed to investigate what doses have been applied in clinical populations, in order to understand the active range of CBD in a variety of medical contexts. Methods Publications involving administration of CBD alone were collected by searching PubMed, EMBASE and ClinicalTrials.gov. Results A...

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British Journal of Clinical Pharmacology

Appropriateness of prescription of oral anticoagulant therapy in acutely hospitalized older people with atrial fibrillation. Secondary analysis of the SIM‐AF cluster randomized clinical trial

Published: 19 July 2019

Author(s): Stefania Antoniazzi, Ilaria Ardoino, Marco Proietti, Valter Monzani, Pier Mannuccio Mannucci, Alessandro Nobili, Carlotta Franchi

Aims To assess the appropriateness of oral anticoagulant (OAC) prescription and its associated factors in acutely hospitalized elderly patients. Methods Data were obtained from the prospective phase of SIM‐AF (SIMulation‐based technologies to improve the appropriate use of oral anticoagulants in hospitalized elderly patients with Atrial Fibrillation) randomized controlled trial, aimed to test whether an educational intervention improved OAC prescription, compared to current clinical practice,...

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British Journal of Clinical Pharmacology

High and variable population prevalence of HLA‐B*56:02 in indigenous Australians and relation to phenytoin‐associated drug reaction with eosinophilia and systemic symptoms

Published: 19 July 2019

Author(s): Andrew A. Somogyi, Daniel T. Barratt, Elizabeth J. Phillips, Kylies Moore, Fahmida Ilyas, Genevieve M. Gabb

Phenytoin drug reaction with eosinophilia and systemic symptoms (DRESS) in 3 Aboriginal Australians positive for HLA‐B*56:02 has been previously reported. We report the allele frequency of HLA‐B*56:02 in 2 South Australian populations, 1 Aboriginal (4.8%, 95% confidence interval 2.4–7.8%) and the other European (0%). We compared the frequency with publicly available information on HLA‐B*56:02 status in other Indigenous Australian (n = 4) and European Australian cohorts (n = 1). In the...

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Journal of the American Ceramic Society

How carbonation curing influences ca leaching of Portland cement paste: Mechanism and mathematical modeling

Published: 19 July 2019

Author(s): Tiefeng Chen, Xiaojian Gao

Abstract Carbonation curing provides a promising method for both CO2 sequestration and strength improvement of cement‐based materials. To date, there is little knowledge about the influence of carbonation curing on Ca leaching resistance of cement‐based materials due to the occurrence of both physical and chemical transformation. It was the first time that Ca solid‐liquid equilibrium curves were experimentally established for cement pastes with different carbonation degrees in this paper....

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Journal of the American Ceramic Society

Dual‐activator luminescence of LuAG:Mn4+/Tb3+ phosphor for optical thermometry

Published: 19 July 2019

Author(s): Chunyan Xie, Lu Zhao, Bin Jiang, Jiashan Mao, Yan Lin, Peng Wang, Xiantao Wei, Min Yin, Yonghu Chen

Abstract Mn4+ and Tb3+ singly doped and Mn4+/Tb3+ codoped lutetium aluminum garnet (Lu3Al5O12, or simply LuAG) phosphors were synthesized and investigated for the application of optical thermometry. X‐ray powder diffraction and luminescence spectroscopy measurements were performed on all samples to analyze their crystal phases and optical properties. In particular, temperature‐dependent luminescence of the LuAG:Mn4+/Tb3+ sample was measured at the temperature range of 270–420 K. The results...

thumbnail image: Journal of the American Ceramic Society

Journal of the American Ceramic Society

Microstructural, magnetic, and hyperfine characterizations of Cu‐doped cobalt ferrite nanoparticles

Published: 19 July 2019

Author(s): Mritunjoy Prasad Ghosh, Samrat Mukherjee

Abstract We have investigated the structural and magnetic properties of polycrystalline Cu‐substituted cobalt ferrite (CuxCo1−xFe2O4: x = 0.00, 0.15, 0.30, 0.45, 0.60) nanoparticles, synthesized via chemical coprecipitation method. The prepared samples were of single phase as confirmed by X‐ray diffraction analysis. The mean crystallite size ranged from 44 to 65 nm was obtained using Scherrer's formula. M‐T curves revealed that the Curie temperature of all the samples was above room...

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Proteins: Structure, Function, and Bioinformatics

Multimapping confounds ribosome profiling analysis: A case‐study of the Hsp90 molecular chaperone

Published: 19 July 2019

Author(s): Jackson C. Halpin, Radhika Jangi, Timothy O. Street

Abstract Ribosome profiling (Ribo‐seq) can potentially provide detailed information about ribosome position on transcripts and estimates of protein translation levels in vivo. Hsp90 chaperones, which play a critical role in stress tolerance, have characteristic patterns of differential expression under nonstressed and heat shock conditions. By analyzing published Ribo‐seq data for the Hsp90 chaperones in S. cerevisiae, we find wide‐ranging artifacts originating from “multimapping” reads (reads...

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Most-accessed articles from each ChemPubSoc Europe, ACES, and GDCh journal

February 2019

 


Pingyu Zhang, Huaiyi Huang, Samya Banerjee, Guy J. Clarkson, Chen Ge, Cinzia Imberti, Peter J. Sadler
Nucleus-Targeted Organoiridium-Albumin Conjugate for Photodynamic Cancer Therapy [Communication]
Angew. Chem. Int. Ed. 2019, vol. 58, p. 2350

Marion Rusch, Arnaud Thevenon, Dominic Hoepfner, Thomas Aust, Christian Studer, Maude Patoor, Patrick Rollin, Madeleine Livendahl, Beatrice Ranieri, Esther Schmitt, Carsten Spanka, Karl Gademann, Laure C. Bouchez
Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin [Communication]
ChemBioChem 2019, vol. 20, p. 644

Wei Jin, Laura Pastor-Pérez, DeKui Shen, Antonio Sepúlveda-Escribano, Sai Gu, Tomas Ramirez Reina
Catalytic Upgrading of Biomass Model Compounds: Novel Approaches and Lessons Learnt from Traditional Hydrodeoxygenation - a Review [Review]
ChemCatChem 2019, vol. 11, p. 924

Dieter Wöhrle
Kunststoffe [Artikel]
Chem. Unserer Zeit 2019, vol. 53, p. 50

Thomas Wirth
Meet the Board of ChemistryOpen: Thomas Wirth [Meet the Board]
ChemistryOpen 2019, vol. 8, p. 251

Lei Han, Meng-Ke Wu, Fei-Yan Yi, Dongxiao Chen, Hai-Long Jiang
Chemical Sensors Based on Metal-Organic Frameworks [Review]
ChemPlusChem 2016, vol. 81, p. 675

Miaofang Chi, Harry M. Meyer, Zili Wu, Liangbo Liang, Peter V. Bonnesen, Dale K. Hensley, Rui Peng, Yang Song, Cheng Ma, Bobby G. Sumpter, Adam J. Rondinone
High-Selectivity Electrochemical Conversion of CO2 to Ethanol using a Copper Nanoparticle/N-Doped Graphene Electrode [Full Paper]
ChemistrySelect 2016, vol. 1, p. 6055

Hubert Rauscher, Kirsten Rasmussen, Birgit Sokull-Klüttgen
Regulatory Aspects of Nanomaterials in the EU [Research Article]
Chem. Ing. Tech. 2017, vol. 89, p. 224

Abas Mohsenzadeh, Akram Zamani, Mohammad J. Taherzadeh
Bioethylene Production from Ethanol: A Review and Techno-economical Evaluation [Review]
ChemBioEng Rev. 2017, vol. 4, p. 75

Mao Jiang, Kangli Wang, Shu Gao, Ruxing Wang, Jing Han, Jie Yan, Shijie Cheng, Kai Jiang
Selenium as Extra Binding Site for Sulfur Species in Sulfurized Polyacrylonitrile Cathodes for High Capacity Lithium-Sulfur Batteries [Article]
CHEMELECTROCHEM 2019, vol. 6, p. 1365

Tianchao Niu, Jialin Zhang, Wei Chen
Surface Engineering of Two-Dimensional Materials [Focus Review]
ChemNanoMat 2019, vol. 5, p. 6

Dennis Rottschäfer, Beate Neumann, Hans-Georg Stammler, Ryohei Kishi, Masayoshi Nakano, Rajendra S. Ghadwal
A Phosphorus Analogue of p-Quinodimethane with a Planar P4 Ring: A Metal-Free Diphosphorus Source [Communication]
Chem. Eur. J. 2019, vol. 25, p. 3244

Sandip G. Agalave, Suleman R. Maujan, Vandana S. Pore
Click Chemistry: 1,2,3‐Triazoles as Pharmacophores [Focus Review]
Chem. Asian J. 2011, vol. 6, p. 2696

Arun K. Sinha, Danish Equbal
Thiol−Ene Reaction: Synthetic Aspects and Mechanistic Studies of an Anti-Markovnikov-Selective Hydrothiolation of Olefins [Focus Review]
Asian J. Org. Chem. 2019, vol. 8, p. 32

Hartmut Beck, Mario Jeske, Kai Thede, Friederike Stoll, Ingo Flamme, Metin Akbaba, Jens-Kerim Ergüden, Gunter Karig, Jörg Keldenich, Felix Oehme, Hans-Christian Militzer, Ingo V. Hartung, Uwe Thuss
Discovery of Molidustat (BAY 85-3934): A Small-Molecule Oral HIF-Prolyl Hydroxylase (HIF-PH) Inhibitor for the Treatment of Renal Anemia [Full Paper]
ChemMedChem 2018, vol. 13, p. 988

Gloria Tabacchi
Supramolecular Organization in Confined Nanospaces [Review]
ChemPhysChem 2018, vol. 19, p. 1249

Hiroki Tanaka, Yoshihisa Inoue, Tadashi Mori
Circularly Polarized Luminescence and Circular Dichroisms in Small Organic Molecules: Correlation between Excitation and Emission Dissymmetry Factors [Review]
ChemPhotoChem 2018, vol. 2, p. 386

An-Na Cho, Nam-Gyu Park
Impact of Interfacial Layers in Perovskite Solar Cells [Review]
ChemSusChem 2017, vol. 10, p. 3687

Didier Astruc
Why is Ferrocene so Exceptional? [Microreview]
Eur. J. Inorg. Chem. 2017, p. 6

Mabuatsela V. Maphoru, Josef Heveling, Sreejarani Kesavan Pillai
Solvent and Temperature Effects on the Platinum‐Catalyzed Oxidative Coupling of 1‐Naphthols [Full Paper]
Eur. J. Org. Chem. 2016, p. 331

Cover Picture Lebensmittelchemie 1/2019 [Cover Picture]
Lebensmittelchemie 2019, vol. 73

Elementerätsel 1 [Wissenschaft + Forschung]
Nachr. Chem. 2019, vol. 67, p. 37

Schüleraufgabe: CHEMKON 2/2017 [Schüleraufgabe]
CHEMKON 2017, vol. 24, p. 91

Zheng Ma, Douglas R. MacFarlane, Mega Kar
Mg Cathode Materials and Electrolytes for Rechargeable Mg Batteries: A Review [Minireview]
Batteries & Supercaps 2019, vol. 2, p. 115

Catharina Goedecke
Why Does Iodine Turn Starch Blue?
ChemViews Magazine 2016

Most cited articles from each ChemPubSoc Europe, ACES, and GDCh journal


2017

 


Eric J. Popczun, Carlos G. Read, Christopher W. Roske, Nathan S. Lewis, Raymond E. Schaak
Highly Active Electrocatalysis of the Hydrogen Evolution Reaction by Cobalt Phosphide Nanoparticles
Angew. Chem. Int. Ed. 2014, vol. 53, pp. 5427–5430

Philippe Compain, Anne Bodlenner
The Multivalent Effect in Glycosidase Inhibition: A New, Rapidly Emerging Topic in Glycoscience [Minireview]
ChemBioChem 2014, vol. 15, pp. 1239–1251

Zhi-Yuan Gu, Jihye Park, Aaron Raiff, Zhangwen Wei, Hong-Cai Zhou
Metal–Organic Frameworks as Biomimetic Catalysts [Minireview]
ChemCatChem 2014, vol. 6, pp. 67–75

Anthony J. Arduengo, Roland Krafczyk
Auf der Suche nach Stabilen Carbenen [Organische Chemie]
Chem. Unserer Zeit 1998, vol. 32, pp. 6–14

Félix Sancenón, Lluís Pascual, Mar Oroval, Elena Aznar, Ramón Martínez-Máñez
Gated Silica Mesoporous Materials in Sensing Applications [Review]
ChemistryOpen 2015, vol. 4, pp. 418–437

Jun Pu, Tingting Wang, Haiyang Wang, Yao Tong, Chenchen Lu, Wei Kong, Zhenghua Wang
Direct Growth of NiCo2S4 Nanotube Arrays on Nickel Foam as High-Performance Binder-Free Electrodes for Supercapacitors [Full Paper]
ChemPlusChem 2014, vol. 79, pp. 577–583

Francisco Trespalacios, Ignacio E. Grossmann
Review of Mixed-Integer Nonlinear and Generalized Disjunctive Programming Methods [Review]
Chemie Ingenieur Technik 2014, vol. 86, pp. 991–1012

Xiaosi Zhou, Yu-Guo Guo
Highly Disordered Carbon as a Superior Anode Material for Room-Temperature Sodium-Ion Batteries [Communication]
ChemElectroChem 2014, vol. 1, pp. 83–86

Chuanxi Wang, Zhenzhu Xu, Chi Zhang
Polyethyleneimine-Functionalized Fluorescent Carbon Dots: Water Stability, pH Sensing, and Cellular Imaging [Full Paper]
ChemNanoMat 2015, vol. 1, pp. 122–127

Matthew N. Hopkinson, Basudev Sahoo, Jun-Long Li, Frank Glorius
Dual Catalysis Sees the Light: Combining Photoredox with Organo-, Acid, and Transition-Metal Catalysis [Minireview]
Chemistry – A European Journal 2014, vol. 20, pp. 3874–3886

Yinuo Wu, Jun Wang, Fei Mao, Fuk Yee Kwong
Palladium-Catalyzed Cross-Dehydrogenative Functionalization of C(sp2)–H Bonds [Focus Review]
Chemistry – An Asian Journal 2014, vol. 9, pp. 26–47

Derong Cao, Herbert Meier
Pillar[n]arenes—a Novel, Highly Promising Class of Macrocyclic Host Molecules [Focus Review]
Asian Journal of Organic Chemistry 2014, vol. 3, pp. 244–262

Daniel Gallenkamp, Kathy A. Gelato, Bernard Haendler, Hilmar Weinmann
Bromodomains and Their Pharmacological Inhibitors [Review]
ChemMedChem 2014, vol. 9, pp. 438–464

Antonio Bauzá, Tiddo J. Mooibroek, Antonio Frontera
The Bright Future of Unconventional σ/π-Hole Interactions [Review]
ChemPhysChem 2015, vol. 16, pp. 2496–2517

Ksenia S. Egorova, Valentine P. Ananikov
Toxicity of Ionic Liquids: Eco(cyto)activity as Complicated, but Unavoidable Parameter for Task-Specific Optimization [Review]
ChemSusChem 2014, vol. 7, pp. 336–360

Shunichi Fukuzumi, Dachao Hong
Homogeneous versus Heterogeneous Catalysts in Water Oxidation [Microreview]
Eur. J. Inorg. Chem. 2014, pp. 645–659

Fabien Toulgoat, Sébastien Alazet, Thierry Billard
Direct Trifluoromethylthiolation Reactions: The “Renaissance” of an Old Concept [Microreview]
Eur. J. Org. Chem. 2014, pp. 2415–2428

David Schweinfurth, Naina Deibel, Fritz Weisser, Biprajit Sarkar
Mit Klick zu neuen Liganden [Magazin]
Nachr. Chem. 2011, vol. 59, pp. 937–941

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