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Journal of Pharmacy and Pharmacology

The efficacy of microemulsion‐based delivery to improve vitamin E properties: evaluation of the antinociceptive, antioxidant, antidepressant‐ and anxiolytic‐like activities in mice

Published: 25 September 2018

Author(s): Ethel A. Wilhelm, Ane G. Vogt, Angélica S. Reis, Mikaela P. Pinz, Jaqueline F. Souza, Sandra E. Haas, Albanin A. M. Pereira, André R. Fajardo, Cristiane Luchese

Abstract Objectives A microemulsion‐based delivery system was designed to improve vitamin E (VE) properties, and its antinociceptive, antioxidant, antidepressant‐ and anxiolytic‐like activities in mice were evaluated. Methods Male Swiss mice received, by intragastric route, canola oil (20 ml/kg), blank microemulsion (B‐ME) (20 ml/kg), VE free (VE‐F)...

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Journal of Pharmacy and Pharmacology

Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats

Published: 25 September 2018

Author(s): Jann‐Inn Tzeng, Chong‐Chi Chiu, Jhi‐Joung Wang, Ching‐Hsia Hung, Yu‐Wen Chen

Abstract Objectives The aim of this experiment was mainly to examine the effects of intrathecally injected doxylamine and triprolidine, two antihistamine drugs spinal motor and sensory functions. Methods After intrathecally injecting the rats with five different doses, the dose—response curves of spinal sensory and motor block with doxylamine and...

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Journal of Pharmacy and Pharmacology

Benzyl sulforaphane is superior to sulforaphane in inhibiting the Akt/ MAPK and activating the Nrf2/ ARE signalling pathways in HepG2 cells

Published: 25 September 2018

Author(s): Jie Ren, Ling Yuan, Yue Wang, Guangtong Chen, Kun Hu

Abstract Objectives Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, has been reported to own anticarcinogenic, antiinflammatory and cancer chemopreventive properties. Benzyl sulforaphane (BSFN) was a derivative of SFN which was designed and synthesized by our laboratory. Here, the cancer prevention and anticancer effects of BSFN on human hepatoma (HepG2) cells were investigated. ...

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Journal of Pharmacy and Pharmacology

Total flavones of Rhododendron simsii Planch flower protect isolated rat heart from ischaemia‐reperfusion injury and its mechanism of UTR ‐RhoA‐ ROCK pathway inhibition

Published: 25 September 2018

Author(s): Xiao‐Qing Sun, Shuo Chen, Liang‐Fang Wang, Zhi‐Wu Chen

Abstract Objectives Total flavones of Rhododendron simsii Planch flower (TFR) are an effective part extracted from the flower. The present study was designed to investigate the protective effect of TFR in isolated rat heart following global ischaemia‐reperfusion and the possible underlying mechanisms. Methods Langendorff perfusion apparatus was used to perfuse...

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Journal of Pharmacy and Pharmacology

PPARα‐independent action against metabolic syndrome development by fibrates is mediated by inhibition of STAT3 signalling

Published: 25 September 2018

Author(s): Huiying Hua, Julin Yang, Hante Lin, Yang Xi, Manyun Dai, Gangming Xu, Fuyan Wang, Lihong Liu, Tingqi Zhao, Jing Huang, Frank J. Gonzalez, Aiming Liu

Abstract Objectives Metabolic syndrome (MS) is the concurrence of at least three of five medical conditions: obesity, high blood pressure, insulin resistance, high serum triglyceride (TG) and low serum high‐density lipoprotein levels. While fibrates are used to treat disorders other than the lowering serum TG, the mechanism by which fibrates decrease MS has not been established. ...

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Phytotherapy Research

Cyanidin‐3‐glucoside attenuates the angiogenesis of breast cancer via inhibiting STAT3/VEGF pathway

Published: 25 September 2018

Author(s): Xiao Ma, Shilong Ning

Angiogenesis plays a pivotal role in breast cancer progression. Cyanidin‐3‐glucoside (C3G), one of the most widely distributed anthocyanins in edible fruits, shows antioxidative and anti‐inflammatory property as well as induction of breast cancer cells apoptosis. However, the effect of C3G on breast cancer‐induced angiogenesis remains unknown. In the present study, we found that C3G could attenuate breast cancer‐induced angiogenesis via...

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Peptide Science

Effect of cellular polyanion mimetics on tau peptide aggregation

Published: 25 September 2018

Author(s): Tania Ismail, Mathumai Kanapathipillai

Tau protein aggregation is believed to be one of the key drivers of Alzheimer's disease. The two hexapeptide amino acid sequences 306VQIVYK311 and 275VQIINK280 of the tau protein are responsible for aggregation, and subsequent functional loss leading to Alzheimer's progression. Hence, it is important to understand the factors that promote the self‐aggregation of this tau peptide fragments. Cellular microenvironmental polyanions are known...

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Phytotherapy Research

Stevia rebaudiana tea prevents experimental cirrhosis via regulation of NF‐κB, Nrf2, transforming growth factor beta, Smad7, and hepatic stellate cell activation

Published: 25 September 2018

Author(s): Erika Ramos‐Tovar, Rosa E. Flores‐Beltrán, Silvia Galindo‐Gómez, Eunice Vera‐Aguilar, Araceli Diaz‐Ruiz, Sergio Montes, Javier Camacho, Víctor Tsutsumi, Pablo Muriel

Stevia has been shown to prevent oxidative stress and inflammation in carbon tetrachloride‐induced cirrhosis models. This study aimed to investigate the ability of an aqueous extract of stevia (AES) to prevent thioacetamide (TAA)‐induced cirrhosis in rats and to explore its mechanism of action. Liver cirrhosis was established by administering TAA (200 mg/kg by i.p. injections three times a week for 10 weeks); AES was...

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Chemical Biology & Drug Design

Pharmacological and SAR analysis of the LINS 01 compounds at the human histamine H 1 , H 2 , and H 3 receptors

Published: 25 September 2018

Author(s): Michelle Fidelis Corrêa, Álefe Jhonatas Ramos Barbosa, Gustavo Ariel Borges Fernandes, Jillian G. Baker, João Paulo dos Santos Fernandes

Abstract Histamine is a transmitter that activates the four receptors H1R to H4R. The H3R is found in the nervous system as an autoreceptor and heteroreceptor, and controls the release of neurotransmitters, making it a potential drug target for neuropsychiatric conditions. We have previously reported that the 1‐(2,3‐dihydro‐1‐benzofuran‐2‐yl)methylpiperazines (LINS01 compounds) have the selectivity for the H3R over the H4R. Here, we describe...

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Pest Management Science

Enhancing RNAi by using concatemerized double‐stranded RNA

Published: 25 September 2018

Author(s): Gaddelapati Sharath Chandra, Ramaswamy Asokan, Maligeppagol Manamohan, Nallur Krishna Kumar

Abstract BACKGROUND RNA interference (RNAi) is a potential tool for functional characterization of genes and also in the management of insect pests. Accumulated literature reveals that the RNAi efficiency varies among insect species and is reported to be less efficient in lepidopteran insects. RESULTS We attempted to enhance RNAi efficiency by...

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Most-accessed articles from each ChemPubSoc Europe, ACES, and GDCh journal

August 2018


Sunggi Lee, Han Yong Bae, Benjamin List
Can a Ketone Be More Reactive than an Aldehyde? Catalytic Asymmetric Synthesis of Substituted Tetrahydrofurans [Communication]
Angew. Chem. Int. Ed. 2018, vol. 57, p. 12162

Veeresh Juturu, Jin Chuan Wu
Heterologous Protein Expression in Pichia pastoris: Latest Research Progress and Applications [Review]
ChemBioChem 2018, vol. 19, p. 7

Isabela C. Man, Hai-Yan Su, Federico Calle-Vallejo, Heine A. Hansen, José I. Martínez, Nilay G. Inoglu, John Kitchin, Thomas F. Jaramillo, Jens K. Nørskov, Jan Rossmeisl
Universality in Oxygen Evolution Electrocatalysis on Oxide Surfaces [Full Paper]
ChemCatChem 2011, vol. 3, p. 1159

Chemiestudiengänge und Berufsbilder [Editorial]
Chem. Unserer Zeit 2018, vol. 52, p. 206

Balaram Mukhopadhyay, Rituparna Das
Chemical O-Glycosylations: An Overview [Review]
ChemistryOpen 2016, vol. 5, p. 401

Lei Han, Meng-Ke Wu, Fei-Yan Yi, Dongxiao Chen, Hai-Long Jiang
Chemical Sensors Based on Metal-Organic Frameworks [Review]
ChemPlusChem 2016, vol. 81, p. 675

Miaofang Chi, Harry M. Meyer, Zili Wu, Liangbo Liang, Peter V. Bonnesen, Dale K. Hensley, Rui Peng, Yang Song, Cheng Ma, Bobby G. Sumpter, Adam J. Rondinone
High-Selectivity Electrochemical Conversion of CO2 to Ethanol using a Copper Nanoparticle/N-Doped Graphene Electrode [Full Paper]
ChemistrySelect 2016, vol. 1, p. 6055

Peter Buchholz, Torsten Brandenburg
Demand, Supply, and Price Trends for Mineral Raw Materials Relevant to the Renewable Energy Transition Wind Energy, Solar Photovoltaic Energy, and Energy Storage [Review]
Chem. Ing. Tech. 2018, vol. 90, p. 141

Abas Mohsenzadeh, Akram Zamani, Mohammad J. Taherzadeh
Bioethylene Production from Ethanol: A Review and Techno-economical Evaluation [Review]
ChemBioEng Rev. 2017, vol. 4, p. 75

Lantao Liu, Yanli Zhou, Shuang Liu, Maotian Xu
The Applications of Metal−Organic Frameworks in Electrochemical Sensors [Review]
ChemElectroChem 2018, vol. 5, p. 6

Amit Kumar, Qiang Xu
Two-Dimensional Layered Materials as Catalyst Supports [Focus Review]
ChemNanoMat 2018, vol. 4, p. 28

Andreas Schaate, Pascal Roy, Adelheid Godt, Jann Lippke, Florian Waltz, Michael Wiebcke, Peter Behrens
Modulated Synthesis of Zr‐Based Metal–Organic Frameworks: From Nano to Single Crystals [Full Paper]
Chem. Eur. J. 2011, vol. 17, p. 6643

Yuhong Wang, Yiming Li, Xuefeng Jiang
Sulfur-Center-Involved Photocatalyzed Reactions [Focus Review]
Chem. Asian J. 2018, vol. 13, p. 2208

Tatsuhiko Yoshino, Shigeki Matsunaga
Cobalt-Catalyzed C(sp3)−H Functionalization Reactions [Focus Review]
Asian J. Org. Chem. 2018, vol. 7, p. 1193

Hartmut Beck, Mario Jeske, Kai Thede, Friederike Stoll, Ingo Flamme, Metin Akbaba, Jens-Kerim Ergüden, Gunter Karig, Jörg Keldenich, Felix Oehme, Hans-Christian Militzer, Ingo V. Hartung, Uwe Thuss
Discovery of Molidustat (BAY 85-3934): A Small-Molecule Oral HIF-Prolyl Hydroxylase (HIF-PH) Inhibitor for the Treatment of Renal Anemia [Full Paper]
ChemMedChem 2018, vol. 13, p. 988

Gloria Tabacchi
Supramolecular Organization in Confined Nanospaces [Review]
ChemPhysChem 2018, vol. 19, p. 1249

Philipp Gotico, Antonio Del Vecchio, Davide Audisio, Annamaria Quaranta, Zakaria Halime, Winfried Leibl, Ally Aukauloo
Visible-Light-Driven Reduction of CO2 to CO and Its Subsequent Valorization in Carbonylation Chemistry and 13C Isotope Labeling [Communication]
ChemPhotoChem 2018, vol. 2, p. 715

An-Na Cho, Nam-Gyu Park
Impact of Interfacial Layers in Perovskite Solar Cells [Review]
ChemSusChem 2017, vol. 10, p. 3687

Ross J. Marshall, Ross S. Forgan
Postsynthetic Modification of Zirconium Metal-Organic Frameworks [Microreview]
Eur. J. Inorg. Chem. 2016, p. 4310

Miquel A. Pericàs
ICIQ: A 15-Year Journey [Guest Editorial]
Eur. J. Org. Chem. 2018, p. 3880

Cover Picture Lebensmittelchemie 4/2018 [Cover Picture]
Lebensmittelchemie 2018, vol. 72

Lena J. Daumann
Wirklich unzertrennlich? Seltene Erden trennen und recyclen [Wissenschaft & Forschung]
Nachr. Chem. 2018, vol. 66, p. 597

Alexander Engl, Alexandra Schmelzer, Björn Risch
Chemie Pur - Unterrichten in der Natur: Ätherischen Ölen auf der Spur [Artikel]
CHEMKON 2018, vol. 25, p. 7

Catharina Goedecke
Why Does Iodine Turn Starch Blue?
ChemViews Magazine 2016

Most cited articles from each ChemPubSoc Europe, ACES, and GDCh journal



Shoujun Zhu, Qingnan Meng, Lei Wang, Junhu Zhang, Yubin Song, Han Jin, Kai Zhang, Hongchen Sun, Haiyu Wang, Bai Yang
Highly Photoluminescent Carbon Dots for Multicolor Patterning, Sensors, and Bioimaging
Angew. Chem. Int. Ed. 2013, vol. 52, pp. 3953–3957

Balayeshwanth R. Vummidi, Jawad Alzeer, Nathan W. Luedtke
Fluorescent Probes for G-Quadruplex Structures [Review]
ChemBioChem 2013, vol. 14, pp. 540–558

Zhi-Yuan Gu, Jihye Park, Aaron Raiff, Zhangwen Wei, Hong-Cai Zhou
Metal–Organic Frameworks as Biomimetic Catalysts [Minireview]
ChemCatChem 2014, vol. 6, pp. 67–75

Anthony J. Arduengo, Roland Krafczyk
Auf der Suche nach Stabilen Carbenen [Organische Chemie]
Chem. Unserer Zeit 1998, vol. 32, pp. 6–14

Marc Steinmetz, Stefan Grimme
Benchmark Study of the Performance of Density Functional Theory for Bond Activations with (Ni,Pd)-Based Transition-Metal Catalysts [Full Paper]
ChemistryOpen 2013, vol. 2, pp. 115–124

Philipp Scharf, Jens Müller
Nucleic Acids With Metal-Mediated Base Pairs and Their Applications [Review]
ChemPlusChem 2013, vol. 78, pp. 20–34

Philipp Kaiser, Rajabhau?Bajirao Unde, Christoph Kern, Andreas Jess
Production of Liquid Hydrocarbons with CO2 as Carbon Source based on Reverse Water-Gas Shift and Fischer-Tropsch Synthesis [Research Article]
Chem. Ing. Tech. 2013, vol. 85, pp. 489–499

Xiaosi Zhou, Yu-Guo Guo
Highly Disordered Carbon as a Superior Anode Material for Room-Temperature Sodium-Ion Batteries [Communication]
ChemElectroChem 2014, vol. 1, pp. 83–86

Chuanxi Wang, Zhenzhu Xu, Chi Zhang
Polyethyleneimine-Functionalized Fluorescent Carbon Dots: Water Stability, pH Sensing, and Cellular Imaging [Full Paper]
ChemNanoMat 2015, vol. 1, pp. 122–127

Konggang Qu, Jiasi Wang, Jinsong Ren, Xiaogang Qu
Carbon Dots Prepared by Hydrothermal Treatment of Dopamine as an Effective Fluorescent Sensing Platform for the Label-Free Detection of Iron(III) Ions and Dopamine [Full Paper]
Chem. Eur. J. 2013, vol. 19, pp. 7243–7249

Yinuo Wu, Jun Wang, Fei Mao, Fuk Yee Kwong
Palladium-Catalyzed Cross-Dehydrogenative Functionalization of C(sp2)–H Bonds [Focus Review]
Chem. Asian J. 2014, vol. 9, pp. 26–47

Naohiko Yoshikai, Ye Wei
Synthesis of Pyrroles, Indoles, and Carbazoles through Transition-Metal-Catalyzed C–H Functionalization [Review]
Asian J. Org. Chem. 2013, vol. 2, pp. 466–478

Lluís Ballell, Robert H. Bates, Rob J. Young, Daniel Alvarez-Gomez, Emilio Alvarez-Ruiz, Vanessa Barroso, Delia Blanco, Benigno Crespo, Jaime Escribano, Rubén González, Sonia Lozano, Sophie Huss, Angel Santos-Villarejo, José Julio Martín-Plaza, Alfonso Mendoza, María José Rebollo-Lopez, Modesto Remuiñan-Blanco, José Luis Lavandera, Esther Pérez-Herran, Francisco Javier Gamo-Benito, José Francisco García-Bustos, David Barros, Julia P. Castro, Nicholas Cammack
Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis [Full Paper]
ChemMedChem 2013, vol. 8, pp. 313–321

Peter Politzer, Jane S. Murray
Halogen Bonding: An Interim Discussion [Review]
ChemPhysChem 2013, vol. 14, pp. 278–294

Volker Hessel, Dana Kralisch, Norbert Kockmann, Timothy Noël, Qi Wang
Novel Process Windows for Enabling, Accelerating, and Uplifting Flow Chemistry [Review]
ChemSusChem 2013, vol. 6, pp. 746–789

Helena J. Shepherd, Gábor Molnár, William Nicolazzi, Lionel Salmon, Azzedine Bousseksou
Spin Crossover at the Nanometre Scale [Microreview]
Eur. J. Inorg. Chem. 2013, pp. 653–661

Junichiro Yamaguchi, Kei Muto, Kenichiro Itami
Recent Progress in Nickel-Catalyzed Biaryl Coupling [Microreview]
Eur. J. Org. Chem. 2013, pp. 19–30

David Schweinfurth, Naina Deibel, Fritz Weisser, Biprajit Sarkar
Mit Klick zu neuen Liganden [Magazin]
Nachr. Chem. 2011, vol. 59, pp. 937–941
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