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British Journal of Pharmacology

Inhibition of protein arginine methyltransferase 3 activity selectively impairs liver X receptor‐driven transcription of hepatic lipogenic genes in vivo

Published: 16 June 2018

Author(s): Joya E Nahon, Christianne Groeneveldt, Janine J Geerling, Miranda Eck, Menno Hoekstra

Abstract Background and Purpose Agonists for the liver X receptor (LXR) are considered promising therapeutic moieties in cholesterol‐driven diseases by promoting cellular cholesterol efflux pathways. However, current clinical application of these agents is hampered by concomitant LXR‐induced activation of a lipogenic transcriptional network, leading to hepatic steatosis. Recent studies have suggested that protein ...

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Journal of Clinical Pharmacy and Therapeutics

Low body mass index is a risk factor for hyperkalaemia associated with angiotensin converting enzyme inhibitors and angiotensin II receptor blockers treatments

Published: 16 June 2018

Author(s): T. Hirai, R. Yamaga, A. Fujita, T. Itoh

Summary What is known and objective Angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) represent the cornerstones of hypertension and congestive heart failure treatment. Risk factors for hyperkalaemia associated with ACEI and ARB are chronic kidney disease and concomitant medications which increase serum potassium level. Body mass index (BMI) also affects pharmacokinetics of...

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Journal of Food Science

Quality evaluation of biscuits produced from composite blends of pumpkin seed oil press cake and wheat flour

Published: 16 June 2018

Author(s): Marko Jukić, Jasmina Lukinac, Jaka Čuljak, Mateja Pavlović, Drago Šubarić, Daliborka Koceva Komlenić

Abstract Pumpkin seed oil press cake (PSOPC) is a by‐product of pumpkin oil production, and after cold pressing, a significant amount of oil still remains in the press cake. The aim of this study was to investigate the possible use of PSOPC flour as a substitute for wheat flour in biscuit production and, consequently, for reducing shortening usage. Biscuits have been produced from composite blends of plain white flour and PSOPC...

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Journal of Food Science

Assessing pulsed light treatment on the reduction of aflatoxins in peanuts with and without skin

Published: 16 June 2018

Author(s): Manal O. Abuagela, Basheer M. Iqdiam, Hussein Mostafa, Liwei Gu, Matthew E. Smith, Paul J. Sarnoski

Summary Aflatoxin(s) (AFTs) are secondary metabolites of some Aspergillus molds commonly found in peanuts. This study aimed to reduce AFTs (B1 and B2) on contaminated peanuts (with and without skin) using Pulsed Light (PL) treatment for 1, 2, 3, 4 and 5 min at 5 cm distance from the light strobe. After PL treatment, AFT levels were determined using ELISA and LC‐MS‐MS. Quality parameters of treated peanuts and oil were evaluated by...

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British Journal of Pharmacology

Salt, inflammation, IL‐17 and hypertension

Published: 15 June 2018

Author(s): Ulrich O Wenzel, Marlies Bode, Christian Kurts, Heimo Ehmke

Traditionally, arterial hypertension and subsequent end‐organ damage have been attributed to haemodynamic factors, but increasing evidence indicates that inflammation also contributes to the deleterious consequences of this disease. The immune system has evolved to prevent invasion of foreign microorganisms and to promote tissue healing after injury. However, this beneficial activity comes at a cost of collateral damage when the immune...

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British Journal of Pharmacology

High‐frequency autonomic modulation: a new model for analysis of autonomic cardiac control

Published: 15 June 2018

Author(s): Pascal Champéroux, Pierre Fesler, Sebastien Judé, Serge Richard, Jean‐Yves Le Guennec, Jérôme Thireau

Background and Purpose Increase in high‐frequency beat‐to‐beat heart rate oscillations by torsadogenic hERG blockers appears to be associated with signs of parasympathetic and sympathetic co‐activation which cannot be assessed directly using classic methods of heart rate variability analysis. The present work aimed to find a translational model that would allow this particular state of the autonomic control...

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British Journal of Pharmacology

Hydrogen sulfide pathway and skeletal muscle: an introductory review

Published: 15 June 2018

Author(s): Valentina Vellecco, Chiara Armogida, Mariarosaria Bucci

The presence of the H2S pathway in skeletal muscle (SKM) has recently been established. SKM expresses the three constitutive H2S‐generating enzymes in animals and humans, and it actively produces H2S. The main, recognized molecular targets of H2S, that is, potassium channels and PDEs, have been evaluated in SKM physiology in order to hypothesize a role for H2S signalling. SKM dysfunctions, including muscular dystrophy and malignant hyperthermia, have also been evaluated as...

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British Journal of Pharmacology

PEP06 polypeptide 30 exerts antitumour effect in colorectal carcinoma via inhibiting epithelial–mesenchymal transition

Published: 15 June 2018

Author(s): Siming Yu, Linna Li, Wei Tian, Dan Nie, Wei Mu, Fang Qiu, Yu Liu, Xinghan Liu, Xiaofeng Wang, Zhimin Du, Wen‐Feng Chu, Baofeng Yang

Background and Purpose PEP06, a polypeptide modified from endostatin, was investigated for its antitumour effects on colorectal cancer (CRC) and the possible mechanisms of this antitumour activity were examined in in vitro and in vivo models. Experimental Approach After PEP06 treatment, cell proliferation and migration assays were performed in CRC cells....

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British Journal of Clinical Pharmacology

Pharmacokinetics of cefuroxime in infants and neonates undergoing cardiac surgery

Published: 15 June 2018

Author(s): Ralph Gertler, Michael Gruber, Gunther Wiesner, Stanislas Grassin‐Delyle, Saïk Urien, Peter Tassani‐Prell, Klaus Martin

Aims Very little data exist regarding the effect of cardiopulmonary bypass (CPB) on cefuroxime (CXM) pharmacokinetics in children less than one year of age. Methods 50 mg kg−1 CXM i.v. after induction were followed by 75 mg kg−1 into the CPB circuit. In 42 patients undergoing cardiac surgery, 15–20 samples were obtained between 5 and 360 min...

thumbnail image: British Journal of Clinical Pharmacology

British Journal of Clinical Pharmacology

Statin use associated with lower risk of epilepsy after intracranial haemorrhage: A population‐based cohort study

Published: 15 June 2018

Author(s): Hung‐Wei Lin, Yunn‐Fang Ho, Fang‐Ju Lin

Aims To examine the association between statin use before and after intracranial haemorrhage (ICH) and the risk of poststroke epilepsy (PSE). Methods Patients with new‐onset ICH between 2004 and 2012 were identified from the Taiwan National Health Insurance Research Database. The main outcome was the occurrence of epilepsy after stroke. Multivariable Cox...

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Most-accessed articles from each ChemPubSoc Europe, ACES, and GDCh journal

March 2018


Zhang Luo, Bing Liu
Shape-Tunable Colloids from Structured Liquid Droplet Templates [Cover Picture]
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Coline Jumeaux, Olov Wahlsten, Stephan Block, Eunjung Kim, Rona Chandrawati, Philip D. Howes, Fredrik Höök, Molly M. Stevens
MicroRNA Detection by DNA-Mediated Liposome Fusion [Communication]
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Isabela C. Man, Hai-Yan Su, Federico Calle-Vallejo, Heine A. Hansen, José I. Martínez, Nilay G. Inoglu, John Kitchin, Thomas F. Jaramillo, Jens K. Nørskov, Jan Rossmeisl
Universality in Oxygen Evolution Electrocatalysis on Oxide Surfaces [Full Paper]
ChemCatChem 2011, vol. 3, p. 1159

Matthias Schäfer, Bernhard Hauck, Jochen Kuhn, Roland Ulber
Analytik mit Licht - Das Smartphone-Photometer [Artikel]
Chem. Unserer Zeit 2018, vol. 52, p. 52

Balaram Mukhopadhyay, Rituparna Das
Chemical O-Glycosylations: An Overview [Review]
ChemistryOpen 2016, vol. 5, p. 401

Hanshen Xin, Xike Gao
Application of Azulene in Constructing Organic Optoelectronic Materials: New Tricks for an Old Dog [Minireview]
ChemPlusChem 2017, vol. 82, p. 945

Miaofang Chi, Harry M. Meyer, Zili Wu, Liangbo Liang, Peter V. Bonnesen, Dale K. Hensley, Rui Peng, Yang Song, Cheng Ma, Bobby G. Sumpter, Adam J. Rondinone
High-Selectivity Electrochemical Conversion of CO2 to Ethanol using a Copper Nanoparticle/N-Doped Graphene Electrode [Full Paper]
ChemistrySelect 2016, vol. 1, p. 6055

Hubert Rauscher, Kirsten Rasmussen, Birgit Sokull-Klüttgen
Regulatory Aspects of Nanomaterials in the EU [Research Article]
Chem. Ing. Tech. 2017, vol. 89, p. 224

Abas Mohsenzadeh, Akram Zamani, Mohammad J. Taherzadeh
Bioethylene Production from Ethanol: A Review and Techno-economical Evaluation [Review]
ChemBioEng Rev. 2017, vol. 4, p. 75

Robert A. W. Dryfe, Briony Setterfield-Price, Joanne Tory, František Hartl
[M(CO)4(2,2'-bipyridine)] (M=Cr, Mo, W) Complexes as Efficient Catalysts for Electrochemical Reduction of CO2 at a Gold Electrode [Communication]
ChemElectroChem 2015, vol. 2, p. 213

Yinghui Xue, Qin Zhang, Tao Zhang, Lei Fu
Black Phosphorus: Properties, Synthesis, and Applications in Energy Conversion and Storage [Focus Review]
ChemNanoMat 2017, vol. 3, p. 352

Maximilian Koy, Frederik Sandfort, Adrian Tlahuext-Aca, Linda Quach, Constantin G. Daniliuc, Frank Glorius
Palladium-Catalyzed Decarboxylative Heck-Type Coupling of Activated Aliphatic Carboxylic Acids Enabled by Visible Light [Communication]
Chem. Eur. J. 2018, vol. 24, p. 4552

Jian Lv, Qi Zhang, Mao Cai, Yanfang Han, Sanzhong Luo
Aromatic Aminocatalysis [Focus Review]
Chem. Asian J. 2018, vol. 13, p. 740

Hidetoshi Noda, Naoya Kumagai, Masakatsu Shibasaki
Abstract [Focus Review]
Asian J. Org. Chem. 10.1002/ajoc.201800013

Albert J. Kooistra, Márton Vass, Ross McGuire, Rob Leurs, Iwan J. P. de Esch, Gert Vriend, Stefan Verhoeven, Chris de Graaf
3D-e-Chem: Structural Cheminformatics Workflows for Computer-Aided Drug Discovery [Full Paper]
ChemMedChem 2018, vol. 13, p. 614

Zhoufeng Bian, Sonali Das, Ming Hui Wai, Plaifa Hongmanorom, Sibudjing Kawi
A Review on Bimetallic Nickel-Based Catalysts for CO2 Reforming of Methane [Review]
ChemPhysChem 2017, vol. 18, p. 3117

Turkan Gamze Ulusoy Ghobadi, Amir Ghobadi, Ekmel Ozbay, Ferdi Karadas
Strategies for Plasmonic Hot-Electron-Driven Photoelectrochemical Water Splitting [Review]
ChemPhotoChem 2018, vol. 2, p. 161

An-Na Cho, Nam-Gyu Park
Impact of Interfacial Layers in Perovskite Solar Cells [Review]
ChemSusChem 2017, vol. 10, p. 3687

Jeffrey A. Rood, Sondra E. Hinman, Bruce C. Noll, Kenneth W. Henderson
The Use of Halide-Substituted Anilines for the Formation of Magnesium Imides [Full Paper]
Eur. J. Inorg. Chem. 2008, p. 3935

D. B. Ramachary [Author Profile]
Eur. J. Org. Chem. 10.1002/ejoc.201800182

46. Deutscher Lebensmittelchemikertag 2017 in Würzburg [Tagung]
Lebensmittelchemie 2018, vol. 72, p. 1

Peter Chen
Chemistry 4.0 [Leitartikel]
Nachr. Chem. 2018, vol. 66, p. 203

Ira Caspari, Gisela Weber-Peukert, Nicole Graulich
Der Einsatz von Modellen zum Erkenntnisgewinn / Eine Unterrichtseinheit zur Förderung der Modellkompetenz im Kontext „Batterie“ unter explizitem Einbezug von Schülervorstellungen [Aus der Schule]
CHEMKON 2018, vol. 25, p. 23

Catharina Goedecke
Why Does Iodine Turn Starch Blue?
ChemViews Magazine 2016

Most cited articles from each ChemPubSoc Europe, ACES, and GDCh journal



Shoujun Zhu, Qingnan Meng, Lei Wang, Junhu Zhang, Yubin Song, Han Jin, Kai Zhang, Hongchen Sun, Haiyu Wang, Bai Yang
Highly Photoluminescent Carbon Dots for Multicolor Patterning, Sensors, and Bioimaging
Angew. Chem. Int. Ed. 2013, vol. 52, pp. 3953–3957

Balayeshwanth R. Vummidi, Jawad Alzeer, Nathan W. Luedtke
Fluorescent Probes for G-Quadruplex Structures [Review]
ChemBioChem 2013, vol. 14, pp. 540–558

Zhi-Yuan Gu, Jihye Park, Aaron Raiff, Zhangwen Wei, Hong-Cai Zhou
Metal–Organic Frameworks as Biomimetic Catalysts [Minireview]
ChemCatChem 2014, vol. 6, pp. 67–75

Anthony J. Arduengo, Roland Krafczyk
Auf der Suche nach Stabilen Carbenen [Organische Chemie]
Chem. Unserer Zeit 1998, vol. 32, pp. 6–14

Marc Steinmetz, Stefan Grimme
Benchmark Study of the Performance of Density Functional Theory for Bond Activations with (Ni,Pd)-Based Transition-Metal Catalysts [Full Paper]
ChemistryOpen 2013, vol. 2, pp. 115–124

Philipp Scharf, Jens Müller
Nucleic Acids With Metal-Mediated Base Pairs and Their Applications [Review]
ChemPlusChem 2013, vol. 78, pp. 20–34

Philipp Kaiser, Rajabhau?Bajirao Unde, Christoph Kern, Andreas Jess
Production of Liquid Hydrocarbons with CO2 as Carbon Source based on Reverse Water-Gas Shift and Fischer-Tropsch Synthesis [Research Article]
Chem. Ing. Tech. 2013, vol. 85, pp. 489–499

Xiaosi Zhou, Yu-Guo Guo
Highly Disordered Carbon as a Superior Anode Material for Room-Temperature Sodium-Ion Batteries [Communication]
ChemElectroChem 2014, vol. 1, pp. 83–86

Chuanxi Wang, Zhenzhu Xu, Chi Zhang
Polyethyleneimine-Functionalized Fluorescent Carbon Dots: Water Stability, pH Sensing, and Cellular Imaging [Full Paper]
ChemNanoMat 2015, vol. 1, pp. 122–127

Konggang Qu, Jiasi Wang, Jinsong Ren, Xiaogang Qu
Carbon Dots Prepared by Hydrothermal Treatment of Dopamine as an Effective Fluorescent Sensing Platform for the Label-Free Detection of Iron(III) Ions and Dopamine [Full Paper]
Chem. Eur. J. 2013, vol. 19, pp. 7243–7249

Yinuo Wu, Jun Wang, Fei Mao, Fuk Yee Kwong
Palladium-Catalyzed Cross-Dehydrogenative Functionalization of C(sp2)–H Bonds [Focus Review]
Chem. Asian J. 2014, vol. 9, pp. 26–47

Naohiko Yoshikai, Ye Wei
Synthesis of Pyrroles, Indoles, and Carbazoles through Transition-Metal-Catalyzed C–H Functionalization [Review]
Asian J. Org. Chem. 2013, vol. 2, pp. 466–478

Lluís Ballell, Robert H. Bates, Rob J. Young, Daniel Alvarez-Gomez, Emilio Alvarez-Ruiz, Vanessa Barroso, Delia Blanco, Benigno Crespo, Jaime Escribano, Rubén González, Sonia Lozano, Sophie Huss, Angel Santos-Villarejo, José Julio Martín-Plaza, Alfonso Mendoza, María José Rebollo-Lopez, Modesto Remuiñan-Blanco, José Luis Lavandera, Esther Pérez-Herran, Francisco Javier Gamo-Benito, José Francisco García-Bustos, David Barros, Julia P. Castro, Nicholas Cammack
Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis [Full Paper]
ChemMedChem 2013, vol. 8, pp. 313–321

Peter Politzer, Jane S. Murray
Halogen Bonding: An Interim Discussion [Review]
ChemPhysChem 2013, vol. 14, pp. 278–294

Volker Hessel, Dana Kralisch, Norbert Kockmann, Timothy Noël, Qi Wang
Novel Process Windows for Enabling, Accelerating, and Uplifting Flow Chemistry [Review]
ChemSusChem 2013, vol. 6, pp. 746–789

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Spin Crossover at the Nanometre Scale [Microreview]
Eur. J. Inorg. Chem. 2013, pp. 653–661

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Recent Progress in Nickel-Catalyzed Biaryl Coupling [Microreview]
Eur. J. Org. Chem. 2013, pp. 19–30

David Schweinfurth, Naina Deibel, Fritz Weisser, Biprajit Sarkar
Mit Klick zu neuen Liganden [Magazin]
Nachr. Chem. 2011, vol. 59, pp. 937–941
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