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Journal of Pharmacy and Pharmacology

Influence of paeoniflorin and menthol on puerarin transport across MDCK and MDCKMDR 1 cells as blood–brain barrier in vitro model

Published: 13 December 2017

Author(s): Bing Yang, Shouying Du, Yang Lu, Shan Jia, Mengdi Zhao, Jie Bai, Pengyue Li, Huichao Wu

Abstract Objective Our objective of this research was (1) to investigate the transport characteristics of puerarin through MDCK‐MDR1 and MDCK cells and (2) to evaluate the effects of paeoniflorin and menthol on puerarin transport so as to (3) explore the enhancement mechanism. Methods The cytotoxicity of drugs on MDCK and MDCK‐MDR1 was evaluated by...

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Journal of Pharmacy and Pharmacology

Intestinal P‐glycoprotein inhibitors, benzoxanthone analogues

Published: 13 December 2017

Author(s): Song Wha Chae, Jaeok Lee, Jung Hyun Park, Youngjoo Kwon, Younghwa Na, Hwa Jeong Lee

Abstract Objectives The inhibitors of P‐glycoprotein (P‐gp) which limits an access of exogenous compounds in the luminal membrane of the intestine have been studied to enhance the intestinal P‐gp‐mediated absorption of anticancer drugs. Methods Inhibition of the efflux pump by synthesized benzoxanthone derivatives was investigated in vitro and in vivo. MCF‐7/ADR...

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Journal of Pharmacy and Pharmacology

Differing disintegration and dissolution rates, pharmacokinetic profiles and gastrointestinal tolerability of over the counter ibuprofen formulations

Published: 13 December 2017

Author(s): Ingvar Bjarnason, Ozgur Sancak, Anne Crossley, Andrew Penrose, Angel Lanas

Abstract Objectives Formulations of over the counter (OTC) NSAIDs differ substantially, but information is lacking on whether this alters their gastrointestinal profiles. To assess disintegration and dissolution rates and pharmacokinetics of four preparations of OTC ibuprofen and relate these with spontaneously reported gastrointestinal adverse events. Methods ...

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Computer Graphics Forum

Laplace–Beltrami Operator on Point Clouds Based on Anisotropic Voronoi Diagram

Published: 13 December 2017

Author(s): Hongxing Qin, Yi Chen, Yunhai Wang, Xiaoyang Hong, Kangkang Yin, Hui Huang

Abstract The symmetrizable and converged Laplace–Beltrami operator ( Δ M ) is an indispensable tool for spectral geometrical analysis of point clouds. The Δ M , introduced by Liu et al. [LPG12] is guaranteed to be symmetrizable, but its convergence degrades when it is...

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Journal of Heterocyclic Chemistry

Alkylimidazole‐Based Phosphines as Efficient Ligands for Palladium‐Catalyzed Suzuki Reactions

Published: 13 December 2017

Author(s): Ting Chen, Jin Tao Guan, Zhi Yong Zhang, Jing Jing Chen, Fengyan Liu, Xiaopei Liu

Two series of alkylimidazole‐based phosphines were conveniently synthesized in one step from the corresponding alkylimidazole by selective deprotonation and quenching with chlorodiphenylphosphine. The novel ligands are easily tunable and exhibit good‐to‐excellent performance in the palladium‐catalyzed Suzuki coupling reaction.

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Journal of Heterocyclic Chemistry

The Synthesis of Adamantane Ring Containing Benzimidazole, Benzoxazole, and Imidazo[4,5‐ e ]benzoxazole Derivatives from 3‐Aminophenol

Published: 13 December 2017

Author(s): Marina Soselia, Irina Geibel, Davit Zurabishvili, Shota Samsoniya

Adamantane derivatives containing heterocycles such as benzimidazoles, benzoxazoles, and fused imidazo[4,5‐e]benzoxazoles were synthesized from 3‐aminophenol. The route started with amidation of adamantane‐1‐carboxylic acid chloride with 3‐aminophenol furnishing N‐(3‐hydroxyphenyl)adamantane‐1‐carboxamide. Subsequent nitration gave three regioisomers. After reduction of the nitro groups, the respective aniline derivatives were used in the formation...

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Chinese Journal of Chemistry

Palladium‐Catalyzed Cyclization Reaction of o ‐Haloanilines, CO 2 and Isocyanides: Access to Quinazoline‐2,4(1 H ,3 H )‐diones

Published: 13 December 2017

Author(s): Wen‐Zhen Zhang, Honglin Li, Yang Zeng, Xueyan Tao, Xiaobing Lu

Quinazoline‐2,4(1H,3H)‐diones are core structural subunits frequently found in many biologically important compounds. The reaction of 2‐​aminobenzonitrile and CO2, which was frequently studied, only provided N3‐unsubstituted quinazoline‐2,4(1H,3H)‐dione compounds. Herein we report palladium‐catalyzed cyclization reactions of o‐haloanilines, CO2 and isocyanides to prepare N3‐substituted quinazoline‐2,4(1H,3H)‐diones. Electron‐rich o‐bromoanilines participated in...

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Chinese Journal of Chemistry

Highly Stable Molecular Borromean Rings

Published: 13 December 2017

Author(s): Ye Lu, Yuejian Lin, Zhenhua Li, Guoxin Jin

A series of Cp*Rh‐based molecular Borromean rings (BRs) are prepared from naphthazarine or metallaligand. Some of as‐synthesized BRs display high stability and are formed in high yields in solution. The reason is related to the length ratio of the long‐arm linker and short‐arm linker, where smaller aspect ratios of the metallarectangles promote improved stability and yields of the BRs in solution. Increasing the width of the metallaligand...

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ChemBioChem

A FRET Sensor to Monitor Bivalent SUMO–SIM Interactions in SUMO Chain Binding

Published: 13 December 2017

Author(s): Lisa J. Kost, Henning D. Mootz

Abstract The small ubiquitin‐like modifier (SUMO) can be assembled into polymeric chains as part of its diverse biochemical signal pattern upon conjugation to substrate proteins. SUMO chain recognition is facilitated by receptor proteins that contain at least two SUMO‐interacting motifs (SIMs). Little is known about the structure of SUMO chains, both in an unliganded form and upon complexation with multi‐SIM protein partners. A FRET...

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Angewandte Chemie International Edition

Jan C. M van Hest

Published: 13 December 2017

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Most-accessed articles from each ChemPubSoc Europe, ACES, and GDCh journal

November 2017

 


Pingyu Zhang, Cookson K. C. Chiu, Huaiyi Huang, Yuko P. Y. Lam, Abraha Habtemariam, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Peter B. O'Connor, Hui Chao, Peter J. Sadler
Organoiridium Photosensitizers Induce Specific Oxidative Attack on Proteins within Cancer Cells [Communication]
Angew. Chem. Int. Ed. 2017, vol. 56, p. 14898

Mariam Iftikhar, Tivoli J. Olsen, Kaitlin M. Pugliese, William A. Brown, Joshua N. Smith, Sameeran Kunche, Stephan T. Kudlacek, Callum F. G. Ormonde, Tom Z. Yuan, Colin L. Raston, Gregory A. Weiss
Shear‐Stress‐Mediated Refolding of Proteins from Aggregates and Inclusion Bodies [Communication]
ChemBioChem 2015, vol. 16, p. 393

Isabela C. Man, Hai-Yan Su, Federico Calle-Vallejo, Heine A. Hansen, José I. Martínez, Nilay G. Inoglu, John Kitchin, Thomas F. Jaramillo, Jens K. Nørskov, Jan Rossmeisl
Universality in Oxygen Evolution Electrocatalysis on Oxide Surfaces [Full Paper]
ChemCatChem 2011, vol. 3, p. 1159

Matthias Ducci
Geheimtinten [Artikel]
Chem. Unserer Zeit 2017, vol. 51, p. 228

Balaram Mukhopadhyay, Rituparna Das
Chemical O-Glycosylations: An Overview [Review]
ChemistryOpen 2016, vol. 5, p. 401

Lei Han, Meng-Ke Wu, Fei-Yan Yi, Dongxiao Chen, Hai-Long Jiang
Chemical Sensors Based on Metal-Organic Frameworks [Review]
ChemPlusChem 2016, vol. 81, p. 675

Miaofang Chi, Harry M. Meyer, Zili Wu, Liangbo Liang, Peter V. Bonnesen, Dale K. Hensley, Rui Peng, Yang Song, Cheng Ma, Bobby G. Sumpter, Adam J. Rondinone
High-Selectivity Electrochemical Conversion of CO2 to Ethanol using a Copper Nanoparticle/N-Doped Graphene Electrode [Full Paper]
ChemistrySelect 2016, vol. 1, p. 6055

Ekkehard Schwab, Sebastian Schiebahn, Georg Schaub, Martin Reuter, Konstantin Räuchle, Ludolf Plass, Marcell Peuckert, Anja Metzelthin, Falko Mahlendorf, Wolfram Koch, Renate Hoer, Angelika Heinzel, Sigmar Bräuninger, Martin Bertau, Christian Beilmann, Florian Ausfelder, Ferdi Schüth, Detlef Stolten, Gisa Teßmer, Kurt Wagemann, Karl-Friedrich Ziegahn
Energiespeicherung als Element einer sicheren Energieversorgung [Übersichtsbeitrag]
Chem. Ing. Tech. 2015, vol. 87, p. 17

Abas Mohsenzadeh, Akram Zamani, Mohammad J. Taherzadeh
Bioethylene Production from Ethanol: A Review and Techno-economical Evaluation [Review]
ChemBioEng Rev. 2017, vol. 4, p. 75

Robert A. W. Dryfe, Briony Setterfield-Price, Joanne Tory, František Hartl
[M(CO)4(2,2′‐bipyridine)] (M=Cr, Mo, W) Complexes as Efficient Catalysts for Electrochemical Reduction of CO2 at a Gold Electrode [Communication]
ChemElectroChem 2015, vol. 2, p. 213

Yinghui Xue, Qin Zhang, Tao Zhang, Lei Fu
Black Phosphorus: Properties, Synthesis, and Applications in Energy Conversion and Storage [Focus Review]
ChemNanoMat 2017, vol. 3, p. 352

Andreas Schaate, Pascal Roy, Adelheid Godt, Jann Lippke, Florian Waltz, Michael Wiebcke, Peter Behrens
Modulated Synthesis of Zr‐Based Metal–Organic Frameworks: From Nano to Single Crystals [Full Paper]
Chem. Eur. J. 2011, vol. 17, p. 6643

Sandip G. Agalave, Suleman R. Maujan, Vandana S. Pore
Click Chemistry: 1,2,3‐Triazoles as Pharmacophores [Focus Review]
Chem. Asian J. 2011, vol. 6, p. 2696

Andrea Gualandi, Luca Mengozzi, Pier Giorgio Cozzi
Iron-Promoted Radical Reactions: Current Status and Perspectives [Focus Review]
Asian J. Org. Chem. 2017, vol. 6, p. 1160

Ulrich Lücking, Arne Scholz, Philip Lienau, Gerhard Siemeister, Dirk Kosemund, Rolf Bohlmann, Hans Briem, Ildiko Terebesi, Kirstin Meyer, Katja Prelle, Karsten Denner, Ulf Bömer, Martina Schäfer, Knut Eis, Ray Valencia, Stuart Ince, Franz von Nussbaum, Dominik Mumberg, Karl Ziegelbauer, Bert Klebl, Axel Choidas, Peter Nussbaumer, Matthias Baumann, Carsten Schultz-Fademrecht, Gerd Rühter, Jan Eickhoff, Michael Brands
Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer [Full Paper]
ChemMedChem 2017, vol. 12, p. 1776

Paul J. A. Kenis, Angela Dibenedetto, Tierui Zhang
Carbon Dioxide Utilization Coming of Age [Editorial]
ChemPhysChem 2017, vol. 18, p. 3091

Rebecca Clarke, Kin Lok Ho, Abdulrahman Abdullah Alsimaree, Owen J. Woodford, Paul G. Waddell, Jonathan Bogaerts, Wouter Herrebout, Julian G. Knight, Robert Pal, Thomas J. Penfold, Michael J. Hall
Circularly Polarised Luminescence from Helically Chiral “Confused” N,N,O,C-Boron-Chelated Dipyrromethenes (BODIPYs) [Article]
ChemPhotoChem 2017, vol. 1, p. 513

Holger Dau, Etsuko Fujita, Licheng Sun
Artificial Photosynthesis: Beyond Mimicking Nature [Editorial]
ChemSusChem 2017, vol. 10, p. 4228

Ross J. Marshall, Ross S. Forgan
Postsynthetic Modification of Zirconium Metal-Organic Frameworks [Microreview]
Eur. J. Inorg. Chem. 2016, p. 4310

Salia Tangara, Alice Kanazawa, Sandrine Py
The Baldwin Rearrangement: Synthesis of 2-Acylaziridines [Microreview]
Eur. J. Org. Chem. 2017, p. 6357

Deutscher Lebensmittelchemikertag 2015 in Karlsruhe [Poster]
Lebensmittelchemie 2016, vol. 70, p. 71

Norbert Heeb
Der lange Weg zu sauberem Diesel [Leitartikel]
Nachr. Chem. 2017, vol. 65, p. 1079

Katrin Sommer, Christina Toschka, Laura Schröder, Thomas Philipp Schröder, Henning Steff, Roland A. Fischer
Modellexperimente im Chemieunterricht. [Artikel]
CHEMKON 2017, vol. 24, p. 13

Catharina Goedecke
Why Does Iodine Turn Starch Blue?
ChemViews Magazine 2016

Most cited articles from each ChemPubSoc Europe, ACES, and GDCh journal


2016

 


Shoujun Zhu, Qingnan Meng, Lei Wang, Junhu Zhang, Yubin Song, Han Jin, Kai Zhang, Hongchen Sun, Haiyu Wang, Bai Yang
Highly Photoluminescent Carbon Dots for Multicolor Patterning, Sensors, and Bioimaging
Angew. Chem. Int. Ed. 2013, vol. 52, pp. 3953–3957

Balayeshwanth R. Vummidi, Jawad Alzeer, Nathan W. Luedtke
Fluorescent Probes for G-Quadruplex Structures [Review]
ChemBioChem 2013, vol. 14, pp. 540–558

Zhi-Yuan Gu, Jihye Park, Aaron Raiff, Zhangwen Wei, Hong-Cai Zhou
Metal–Organic Frameworks as Biomimetic Catalysts [Minireview]
ChemCatChem 2014, vol. 6, pp. 67–75

Anthony J. Arduengo, Roland Krafczyk
Auf der Suche nach Stabilen Carbenen [Organische Chemie]
Chem. Unserer Zeit 1998, vol. 32, pp. 6–14

Marc Steinmetz, Stefan Grimme
Benchmark Study of the Performance of Density Functional Theory for Bond Activations with (Ni,Pd)-Based Transition-Metal Catalysts [Full Paper]
ChemistryOpen 2013, vol. 2, pp. 115–124

Philipp Scharf, Jens Müller
Nucleic Acids With Metal-Mediated Base Pairs and Their Applications [Review]
ChemPlusChem 2013, vol. 78, pp. 20–34

Philipp Kaiser, Rajabhau Bajirao Unde, Christoph Kern, Andreas Jess
Production of Liquid Hydrocarbons with CO2 as Carbon Source based on Reverse Water-Gas Shift and Fischer-Tropsch Synthesis [Research Article]
Chem. Ing. Tech. 2013, vol. 85, pp. 489–499

Xiaosi Zhou, Yu-Guo Guo
Highly Disordered Carbon as a Superior Anode Material for Room-Temperature Sodium-Ion Batteries [Communication]
ChemElectroChem 2014, vol. 1, pp. 83–86

Chuanxi Wang, Zhenzhu Xu, Chi Zhang
Polyethyleneimine-Functionalized Fluorescent Carbon Dots: Water Stability, pH Sensing, and Cellular Imaging [Full Paper]
ChemNanoMat 2015, vol. 1, pp. 122–127

Konggang Qu, Jiasi Wang, Jinsong Ren, Xiaogang Qu
Carbon Dots Prepared by Hydrothermal Treatment of Dopamine as an Effective Fluorescent Sensing Platform for the Label-Free Detection of Iron(III) Ions and Dopamine [Full Paper]
Chem. Eur. J. 2013, vol. 19, pp. 7243–7249

Yinuo Wu, Jun Wang, Fei Mao, Fuk Yee Kwong
Palladium-Catalyzed Cross-Dehydrogenative Functionalization of C(sp2)–H Bonds [Focus Review]
Chem. Asian J. 2014, vol. 9, pp. 26–47

Naohiko Yoshikai, Ye Wei
Synthesis of Pyrroles, Indoles, and Carbazoles through Transition-Metal-Catalyzed C–H Functionalization [Review]
Asian J. Org. Chem. 2013, vol. 2, pp. 466–478

Lluís Ballell, Robert H. Bates, Rob J. Young, Daniel Alvarez-Gomez, Emilio Alvarez-Ruiz, Vanessa Barroso, Delia Blanco, Benigno Crespo, Jaime Escribano, Rubén González, Sonia Lozano, Sophie Huss, Angel Santos-Villarejo, José Julio Martín-Plaza, Alfonso Mendoza, María José Rebollo-Lopez, Modesto Remuiñan-Blanco, José Luis Lavandera, Esther Pérez-Herran, Francisco Javier Gamo-Benito, José Francisco García-Bustos, David Barros, Julia P. Castro, Nicholas Cammack
Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis [Full Paper]
ChemMedChem 2013, vol. 8, pp. 313–321

Peter Politzer, Jane S. Murray
Halogen Bonding: An Interim Discussion [Review]
ChemPhysChem 2013, vol. 14, pp. 278–294

Volker Hessel, Dana Kralisch, Norbert Kockmann, Timothy Noël, Qi Wang
Novel Process Windows for Enabling, Accelerating, and Uplifting Flow Chemistry [Review]
ChemSusChem 2013, vol. 6, pp. 746–789

Helena J. Shepherd, Gábor Molnár, William Nicolazzi, Lionel Salmon, Azzedine Bousseksou
Spin Crossover at the Nanometre Scale [Microreview]
Eur. J. Inorg. Chem. 2013, pp. 653–661

Junichiro Yamaguchi, Kei Muto, Kenichiro Itami
Recent Progress in Nickel-Catalyzed Biaryl Coupling [Microreview]
Eur. J. Org. Chem. 2013, pp. 19–30

David Schweinfurth, Naina Deibel, Fritz Weisser, Biprajit Sarkar
Mit Klick zu neuen Liganden [Magazin]
Nachr. Chem. 2011, vol. 59, pp. 937–941
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