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Basic & Clinical Pharmacology & Toxicology

Pharmacokinetics of Transdermal Etofenamate and Diclofenac in Healthy Volunteers

Published: 27 June 2017

Author(s): Sara Drago, Roger Imboden, Philipp Schlatter, Mirabel Buylaert, Stephan Krähenbühl, Juergen Drewe

Abstract Little is known about the course of the plasma concentration and the bioavailability of non‐steroidal anti‐inflammatory drugs (NSAIDs) contained in dermal patches. We compared an etofenamate prototype patch (patent EP 1833471) and a commercially available diclofenac epolamine patch regarding the bioavailability of the active ingredients relative to respective i.m. applications and regarding their plasma concentration–time...

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Basic & Clinical Pharmacology & Toxicology

Severe Acute Valproic Acid Intoxication Successfully Treated with Liver Support Therapy

Published: 27 June 2017

Author(s): Yongchun Ge, Bin Xu, Shuhua Zhu, Chuan Li, Qunpeng He, Tingting Zhu, Rong Fan, Dehua Gong

Abstract Valproic acid (VPA) is widely used for the treatment of epilepsy. However, its overdose can cause intoxication and could be life‐threatening. Due to the lack of specific antidote and poorness of endogenous clearance, extracorporeal treatment for severe intoxication cases is indicated. Here, we report a case of severe intoxication of VPA which was successfully treated with liver support therapy. A previously healthy woman...

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AIChE Journal

Pipe flow of a dense emulsion: Homogeneous shear‐thinning or shear‐induced migration?

Published: 27 June 2017

Author(s): Micheline Abbas, Amélie Pouplin, Olivier Masbernat, Alain Liné, Sandrine Décarre

The flow field of a 70% concentrated noncolloidal o/w emulsion in a pipe has been investigated by means of Particle Image Velocimetry in a matched refractive index medium. At steady state and in laminar regime, the shape of axial velocity profiles is not parabolic and exhibits a shear‐thinning behavior of the dense emulsion, with a flow index of 0.5 and a negligible yield stress (less than 1 Pa). However, instead of a square root law, the...

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Journal of Texture Studies

Texture and breakdown in the mouth: An industrial research approach

Published: 27 June 2017

Author(s): Peter Lillford

Abstract Texture is one of foods' most important qualities, but is a sensory perception by consumers. To understand, predict and design for sensory appeal, we must codify the sensory response and diagnose the physical stimuli in the mouth which give rise to perception. This brief review examines the leading contributions from Szczesniak and Bourne and shows the developments in the field, built on their earlier...

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Palladium‐Catalyzed Ligand‐Controlled Selective Synthesis of Aldehydes and Acids from Aryl Halides and Formic Acid

Published: 27 June 2017

Author(s): Fu‐Peng Wu, Jin‐Bao Peng, Ling‐Shen Meng, Xinxin Qi, Xiao‐Feng Wu

Abstract Selective synthesis is in the core of modern organic chemistry. In this communication, a novel ligand‐dependent palladium‐catalyzed carbonylation procedure for the divergent synthesis of aldehydes and carboxylic acids from easily available aryl halides was established. Under the same reaction conditions, the reaction pathway could be controlled by the ligands applied to give formylated and carboxylated products selectively....

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Synthesis and Antibacterial Activity of Polymerizable Acryloyloxyalkyltriethyl Ammonium Salts

Published: 27 June 2017

Author(s): Raffaella Mancuso, Roberta Amuso, Biagio Armentano, Giuseppe Grasso, Vittoria Rago, Anna Rita Cappello, Francesco Galiano, Alberto Figoli, Giorgio De Luca, Jan Hoinkis, Bartolo Gabriele

Abstract This study reports an efficient and practical synthetic approach for the synthesis of a particularly important class of polymerizable quaternary ammonium salts (PQASs), that is, acryloxyalkyltriethylammonium bromides (AATEABs), which may find application as antimicrobial coatings for commercial membranes with antifouling and anti‐biofouling properties, to be used for wastewater treatment. The synthetic method is based on a...

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Chemie Ingenieur Technik - CIT

Redispersion of Nanoparticle‐Loaded Orodispersible Films: Preservation of Particle Fineness

Published: 27 June 2017

Author(s): Denise Steiner, Jan Henrik Finke, Arno Kwade

Abstract The application of orodispersible films (ODFs) as carrier for drug nanoparticles was discovered a few years ago. Poorly water‐soluble drugs are milled to nanosuspensions to improve their bioavailability. During the manufacturing process they are embedded into a polymer matrix or loaded on the surface of drug‐free ODF templates. The particle size of the particles released from the ODF was measured when redispersed in water....

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Carbon Nanotubes Heavy Metal Detection with Stripping Voltammetry: A Review Paper

Published: 27 June 2017

Author(s): Tingting Wang, Wei Yue

Abstract The challenge of heavy metal detection for environmental, industrial and medical purposes has led to the development of many analytical techniques. Stripping voltammetry is a very sensitive electrochemical method and has been widely used for heavy metal detection. Carbon nanotubes, a well‐studied carbon material with physical and chemical properties suited for electrode material is commonly employed for sensitive and...

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Electrochemical Determination of Label Free BRCA Hybridization by Single Use Antioxidant Modified Electrode

Published: 27 June 2017

Author(s): Merve Muti, Mihrican Muti

Abstract A novel DNA probe based on caffeic acid modified disposable pencil graphite electrodes were developed for the first time for the electrochemical determination of breast cancer gene sequence (BRCA) hybridization. Amino‐linked BRCA probe highly immobilized onto the caffeic acid modified electrode by means of the interaction between the amino group of BRCA probe and the carboxyl group of caffeic acid compared to the bare...

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Ionic Diode Characteristics at a Polymer of Intrinsic Microporosity (PIM) | Nafion “Heterojunction” Deposit on a Microhole Poly(ethylene‐terephthalate) Substrate

Published: 27 June 2017

Author(s): Budi Riza Putra, Barak D.B. Aaronson, Elena Madrid, Klaus Mathwig, Mariolino Carta, Richard Malpass‐Evans, Neil B. McKeown, Frank Marken

Abstract Ionic diode phenomena occur at asymmetric ionomer | aqueous electrolyte microhole interfaces. Depending on the applied potential, either an “open” or a “closed” diode state is observed switching between a high ion flow rate and a low ion flow rate. Physically, the “open” state is associated mainly with conductivity towards the microhole within the ionomer layer and the “closed” state is dominated by restricted...

thumbnail image: Electroanalysis

Most-accessed articles from each ChemPubSoc Europe, ACES, and GDCh journal

April 2017


Xin Mu, Yu Shibata, Yusuke Makida, Gregory C. Fu
Control of Vicinal Stereocenters through Nickel‐Catalyzed Alkyl–Alkyl Cross‐Coupling [Communication]
Angew. Chem. Int. Ed. 2017, vol. 56, p. 5821

Dario Neri
Twenty‐five Years of DNA‐Encoded Chemical Libraries [Editorial]
ChemBioChem 2017, vol. 18, p. 827

Isabela C. Man, Hai‐Yan Su, Federico Calle‐Vallejo, Heine A. Hansen, José I. Martínez, Nilay G. Inoglu, John Kitchin, Thomas F. Jaramillo, Jens K. Nørskov, Jan Rossmeisl
Universality in Oxygen Evolution Electrocatalysis on Oxide Surfaces [Full Paper]
ChemCatChem 2011, vol. 3, p. 1159

Warum brennt Alkohol eigentlich in Wunden? [Treffpunkt Forschung]
Chem. Unserer Zeit 2017, vol. 51, p. 83

Thammadihalli Nanjundaiah Ravishankar, Thippeswamy Ramakrishnappa, Ganganagappa Nagaraju, Hanumanaika Rajanaika
Synthesis and Characterization of CeO2 Nanoparticles via Solution Combustion Method for Photocatalytic and Antibacterial Activity Studies [Full Paper]
ChemistryOpen 2015, vol. 4, p. 146

Hanshen Xin, Xike Gao
Application of Azulene in Constructing Organic Optoelectronic Materials: New Tricks for an Old Dog [Minireview]
ChemPlusChem 2017, 10.1002/cplu.201700039

Yang Song, Rui Peng, Dale K. Hensley, Peter V. Bonnesen, Liangbo Liang, Zili Wu, Harry M. Meyer, Miaofang Chi, Cheng Ma, Bobby G. Sumpter, Adam J. Rondinone
High‐Selectivity Electrochemical Conversion of CO2 to Ethanol using a Copper Nanoparticle/N‐Doped Graphene Electrode [Full Paper]
ChemistrySelect 2016, 10.1002/slct.201601169

Hubert Rauscher, Kirsten Rasmussen, Birgit Sokull‐Klüttgen
Regulatory Aspects of Nanomaterials in the EU [Research Article]
Chem. Ing. Tech. 2017, vol. 89, p. 224

Abas Mohsenzadeh, Akram Zamani, Mohammad J. Taherzadeh
Bioethylene Production from Ethanol: A Review and Techno‐economical Evaluation [Review]
ChemBioEng Rev. 2017, vol. 4, p. 75

Joanne Tory, Briony Setterfield‐Price, Robert A. W. Dryfe, František Hartl
[M(CO)4(2,2′‐bipyridine)] (M=Cr, Mo, W) Complexes as Efficient Catalysts for Electrochemical Reduction of CO2 at a Gold Electrode [Communication]
ChemElectroChem 2015, vol. 2, p. 213

Elke Debroye, Haifeng Yuan, Eva Bladt, Wouter Baekelant, Mark Van der Auweraer, Johan Hofkens, Sara Bals, Maarten B. J. Roeffaers
Facile Morphology‐Controlled Synthesis of Organolead Iodide Perovskite Nanocrystals Using Binary Capping Agents [Communication]
ChemNanoMat 2017, 10.1002/cnma.201700006

Hirotatsu Umihara, Satoshi Yokoshima, Masayuki Inoue, Tohru Fukuyama
Total Synthesis of (−)‐Morphine [Communication]
Chem. Eur. J. 2017, 10.1002/chem.201701438

Sandip G. Agalave, Suleman R. Maujan, Vandana S. Pore
Click Chemistry: 1,2,3‐Triazoles as Pharmacophores [Focus Review]
Chem. Asian J. 2011, vol. 6, p. 2696

Edward J. Emmett, Michael C. Willis
The Development and Application of Sulfur Dioxide Surrogates in Synthetic Organic Chemistry [Focus Review]
Asian J. Org. Chem. 2015, vol. 4, p. 602

Yves P. Auberson, Cara Brocklehurst, Markus Furegati, Thomas C. Fessard, Guido Koch, Andrea Decker, Luigi La Vecchia, Emmanuelle Briard
Improving Nonspecific Binding and Solubility: Bicycloalkyl Groups and Cubanes as para‐Phenyl Bioisosteres [Full Paper]
ChemMedChem 2017, vol. 12, p. 590

Jamie Gibson, Andrew Monkman, Thomas Penfold
The Importance of Vibronic Coupling for Efficient Reverse Intersystem Crossing in TADF molecules [Communication]
ChemPhysChem 2016, 10.1002/cphc.201600662

Jia‐Rong Chen, Dong‐Mei Yan, Qiang Wei, Wen‐Jing Xiao
Photocascade Catalysis: A New Strategy for Cascade Reactions [Concept]
ChemPhotoChem 2017, 10.1002/cptc.201700008

Arjan W. Kleij, Michael North, Atsushi Urakawa
CO2 Catalysis [Editorial]
ChemSusChem 2017, 10.1002/cssc.201700218

Ross J. Marshall, Ross S. Forgan
Postsynthetic Modification of Zirconium Metal‐Organic Frameworks [Microreview]
Eur. J. Inorg. Chem. 2016, 10.1002/ejic.201600394

Burkhard König
Photocatalysis in Organic Synthesis – Past, Present, and Future [Essay]
Eur. J. Org. Chem. 2017, p. 1979

T. Henle
Historisches zur Lebensmittelchemie an der TU Dresden [Artikel]
Lebensmittelchemie 2017, vol. 71, p. 20

Frauke Zbikowski
Vom emissionsfreien Kamin und musikalischen Molekül [Bildung & Gesellschaft]
Nachr. Chem. 2017, vol. 65, p. 478

Katrin Sommer, Christina Toschka, Laura Schröder, Thomas Philipp Schröder, Henning Steff, Roland A. Fischer
Modellexperimente im Chemieunterricht. [Artikel]
CHEMKON 2017, vol. 24, p. 13

Sarah Millar
Tips and Tricks for the Lab: Column Choices
ChemViews Magazine 2012.

Most cited articles from each ChemPubSoc Europe, ACES, and GDCh journal



Shoujun Zhu, Qingnan Meng, Lei Wang, Junhu Zhang, Yubin Song, Han Jin, Kai Zhang, Hongchen Sun, Haiyu Wang, Bai Yang
Highly Photoluminescent Carbon Dots for Multicolor Patterning, Sensors, and Bioimaging
Angew. Chem. Int. Ed. 2013, vol. 52, pp. 3953–3957

Balayeshwanth R. Vummidi, Jawad Alzeer, Nathan W. Luedtke
Fluorescent Probes for G-Quadruplex Structures [Review]
ChemBioChem 2013, vol. 14, pp. 540–558

Zhi-Yuan Gu, Jihye Park, Aaron Raiff, Zhangwen Wei, Hong-Cai Zhou
Metal–Organic Frameworks as Biomimetic Catalysts [Minireview]
ChemCatChem 2014, vol. 6, pp. 67–75

Anthony J. Arduengo, Roland Krafczyk
Auf der Suche nach Stabilen Carbenen [Organische Chemie]
Chem. Unserer Zeit 1998, vol. 32, pp. 6–14

Marc Steinmetz, Stefan Grimme
Benchmark Study of the Performance of Density Functional Theory for Bond Activations with (Ni,Pd)-Based Transition-Metal Catalysts [Full Paper]
ChemistryOpen 2013, vol. 2, pp. 115–124

Philipp Scharf, Jens Müller
Nucleic Acids With Metal-Mediated Base Pairs and Their Applications [Review]
ChemPlusChem 2013, vol. 78, pp. 20–34

Philipp Kaiser, Rajabhau Bajirao Unde, Christoph Kern, Andreas Jess
Production of Liquid Hydrocarbons with CO2 as Carbon Source based on Reverse Water-Gas Shift and Fischer-Tropsch Synthesis [Research Article]
Chem. Ing. Tech. 2013, vol. 85, pp. 489–499

Xiaosi Zhou, Yu-Guo Guo
Highly Disordered Carbon as a Superior Anode Material for Room-Temperature Sodium-Ion Batteries [Communication]
ChemElectroChem 2014, vol. 1, pp. 83–86

Chuanxi Wang, Zhenzhu Xu, Chi Zhang
Polyethyleneimine-Functionalized Fluorescent Carbon Dots: Water Stability, pH Sensing, and Cellular Imaging [Full Paper]
ChemNanoMat 2015, vol. 1, pp. 122–127

Konggang Qu, Jiasi Wang, Jinsong Ren, Xiaogang Qu
Carbon Dots Prepared by Hydrothermal Treatment of Dopamine as an Effective Fluorescent Sensing Platform for the Label-Free Detection of Iron(III) Ions and Dopamine [Full Paper]
Chem. Eur. J. 2013, vol. 19, pp. 7243–7249

Yinuo Wu, Jun Wang, Fei Mao, Fuk Yee Kwong
Palladium-Catalyzed Cross-Dehydrogenative Functionalization of C(sp2)–H Bonds [Focus Review]
Chem. Asian J. 2014, vol. 9, pp. 26–47

Naohiko Yoshikai, Ye Wei
Synthesis of Pyrroles, Indoles, and Carbazoles through Transition-Metal-Catalyzed C–H Functionalization [Review]
Asian J. Org. Chem. 2013, vol. 2, pp. 466–478

Lluís Ballell, Robert H. Bates, Rob J. Young, Daniel Alvarez-Gomez, Emilio Alvarez-Ruiz, Vanessa Barroso, Delia Blanco, Benigno Crespo, Jaime Escribano, Rubén González, Sonia Lozano, Sophie Huss, Angel Santos-Villarejo, José Julio Martín-Plaza, Alfonso Mendoza, María José Rebollo-Lopez, Modesto Remuiñan-Blanco, José Luis Lavandera, Esther Pérez-Herran, Francisco Javier Gamo-Benito, José Francisco García-Bustos, David Barros, Julia P. Castro, Nicholas Cammack
Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis [Full Paper]
ChemMedChem 2013, vol. 8, pp. 313–321

Peter Politzer, Jane S. Murray
Halogen Bonding: An Interim Discussion [Review]
ChemPhysChem 2013, vol. 14, pp. 278–294

Volker Hessel, Dana Kralisch, Norbert Kockmann, Timothy Noël, Qi Wang
Novel Process Windows for Enabling, Accelerating, and Uplifting Flow Chemistry [Review]
ChemSusChem 2013, vol. 6, pp. 746–789

Helena J. Shepherd, Gábor Molnár, William Nicolazzi, Lionel Salmon, Azzedine Bousseksou
Spin Crossover at the Nanometre Scale [Microreview]
Eur. J. Inorg. Chem. 2013, pp. 653–661

Junichiro Yamaguchi, Kei Muto, Kenichiro Itami
Recent Progress in Nickel-Catalyzed Biaryl Coupling [Microreview]
Eur. J. Org. Chem. 2013, pp. 19–30

David Schweinfurth, Naina Deibel, Fritz Weisser, Biprajit Sarkar
Mit Klick zu neuen Liganden [Magazin]
Nachr. Chem. 2011, vol. 59, pp. 937–941
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